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aladotril (Fasidotril)

inhibits neutral endopeptidase; prodrug of aladotrilat

Also Known As:

Fasidotril; BP 1137

Networked: 4 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - aladotril: 4

Experts

1.	Ozdemir, Vural: 1 article (09/2003)
2.	Ozdener, Fatih: 1 article (09/2003)
3.	Azizi, M: 1 article (05/2000)
4.	Boutouyrie, P: 1 article (05/2000)
5.	Bralet, J: 1 article (05/2000)
6.	Gros, C: 1 article (05/2000)
7.	Laurent, S: 1 article (05/2000)
8.	Lecomte, J M: 1 article (05/2000)
9.	Marie, C: 1 article (05/2000)
10.	Schwartz, J C: 1 article (05/2000)

Related Diseases

1.	Hypertension (High Blood Pressure) 09/01/2003 - "Phase II trials to investigate the potential of fasidotril for the treatment of hypertension and CHF had commenced by the late 1990s, and were ongoing in July 2003 in the US and Europe." 09/01/2003 - "Lilly is developing fasidotril, a diester prodrug of the active metabolite fasidotrilat, for the potential treatment of hypertension and congestive heart failure (CHF). " 05/01/2000 - "The aim of this study was to assess the antihypertensive activity of fasidotril, a dual inhibitor of neprilysin (NEP) and angiotensin I-converting enzyme (ACE), in various models of hypertension in rats (spontaneously hypertensive rats [SHR]; renovascular Goldblatt 2-kidney, 1-clip rats; and deoxycorticosterone acetate [DOCA]-salt hypertensive rats) and in patients with mild-to-moderate essential hypertension. "
2.	Myocardial Infarction 12/01/1995 - "Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction." 03/01/1999 - "Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction." 12/01/1995 - "The aim of the present study was to determine, in rats with myocardial infarction, the systemic and cardiac hemodynamic effects of aladotrilat and of its prodrug, aladotril, both of which display inhibitory activity toward both neutral endopeptidase (NEP, EC. "
3.	Essential Hypertension 05/01/2000 - "After a 4-week placebo run-in period, 57 patients with essential hypertension were included in a randomized double-blind, placebo-controlled, parallel-group study and received orally either fasidotril (100 mg twice daily) or placebo for 6 weeks. " 05/01/2000 - "After 42 days, compared with placebo, fasidotril lowered supine systolic and diastolic blood pressures by 7.4/5.4 mm Hg and standing blood pressure by 7.6/6.8 mm Hg. Fasidotril, a dual NEP/ACE inhibitor, was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in patients with essential hypertension." 05/01/2000 - "The aim of this study was to assess the antihypertensive activity of fasidotril, a dual inhibitor of neprilysin (NEP) and angiotensin I-converting enzyme (ACE), in various models of hypertension in rats (spontaneously hypertensive rats [SHR]; renovascular Goldblatt 2-kidney, 1-clip rats; and deoxycorticosterone acetate [DOCA]-salt hypertensive rats) and in patients with mild-to-moderate essential hypertension. "
4.	Infarction (Infarctions) 03/01/1999 - "In rats with moderate infarcts, fasidotril prolonged survival, 50% of the control rats dying during the 40-week observation period compared with 30% of treated rats (P = 0.04, log-rank test)). " 03/01/1999 - "Cardiac hypertrophy was significantly attenuated by fasidotril for the three infarct sizes. "
5.	Heart Failure 09/01/2003 - "Lilly is developing fasidotril, a diester prodrug of the active metabolite fasidotrilat, for the potential treatment of hypertension and congestive heart failure (CHF). "

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
3.	Prodrugs
4.	aladotrilat
5.	Desoxycorticosterone Acetate (DOCA)
6.	Salts
7.	Desoxycorticosterone (Deoxycorticosterone)
8.	Antihypertensive Agents (Antihypertensives)
9.	Acetates (Acetic Acid Esters)
10.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)

Related Therapies and Procedures

1.	Surgical Instruments (Clip)
2.	Therapeutics