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aladotrilat

inhibits neutral endopeptidase; its prodrug is aladrotril

Also Known As:

Fasidotrilat; N-(3-(3,4-methylenedioxyphenyl)-2-mercaptomethyl-1-oxopropyl)-alanine

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - aladotrilat: 4

Experts

1.	Juszczak, Kajetan: 1 article (01/2009)
2.	Machowska, Anna: 1 article (01/2009)
3.	Novak, Paweł: 1 article (01/2009)
4.	Thor, Piotr: 1 article (01/2009)
5.	Ozdemir, Vural: 1 article (09/2003)
6.	Ozdener, Fatih: 1 article (09/2003)

Related Diseases

1.	Myocardial Infarction 12/01/1995 - "The aim of the present study was to determine, in rats with myocardial infarction, the systemic and cardiac hemodynamic effects of aladotrilat and of its prodrug, aladotril, both of which display inhibitory activity toward both neutral endopeptidase (NEP, EC. "
2.	Hypertension (High Blood Pressure) 09/01/2003 - "Lilly is developing fasidotril, a diester prodrug of the active metabolite fasidotrilat, for the potential treatment of hypertension and congestive heart failure (CHF). " 01/01/2009 - "These drugs, such as omapatrilat, sampatrilat, fasidotrilat, by combined inhibition of ACE and degradation of natriuretic peptides and in turn by inhibiting the Renin - Angiotensin - Aldosterone system and potentiating the Natriuretic Peptide system and Kinin system should decrease the mortality rate in the group of patients with hypertension being not adequately controlled with ACE inhibitors. "
3.	Heart Failure 09/01/2003 - "Lilly is developing fasidotril, a diester prodrug of the active metabolite fasidotrilat, for the potential treatment of hypertension and congestive heart failure (CHF). " 06/01/1998 - "Acute natriuretic effect of fasidotrilat, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in rats with heart failure."

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Prodrugs
3.	aladotril (Fasidotril)
4.	Natriuretic Agents
5.	Natriuretic Peptides
6.	Kinins
7.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
8.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
9.	sampatrilat
10.	omapatrilat