|1.||Nguyen, Thi M-D: 1 article (09/2013)|
|2.||Schiller, Peter W: 1 article (09/2013)|
|3.||Chung, Nga N: 1 article (09/2013)|
|4.||Weltrowska, Grazyna: 1 article (09/2013)|
|5.||Wilkes, Brian C: 1 article (09/2013)|
|6.||Salvadori, Severo: 1 article (08/2010)|
|7.||Marczak, Ewa D: 1 article (08/2010)|
|8.||Balboni, Gianfranco: 1 article (08/2010)|
|9.||Ambo, Akihiro: 1 article (08/2010)|
|10.||Lazarus, Lawrence H: 1 article (08/2010)|
06/01/1998 - "Asymmetrical pseudodipeptides, Y-Xaa-gSer-Y (Y = Z, Fmoc; Xaa = Cha, Phe, Tyr, Tic) showed weak inhibitory potency (IC50 > or = 5 mumol/l), whereas the corresponding pseudotripeptides displayed a more significant HIV-1 Pr inhibition: Fmoc-Tic-gSer-Tic-Fmoc (Fmoc = fluorenylmethyloxycarbonyl, Tic = 1,2,3,4-tetradroisoquinoline-3-carboxylic acid) was the most potent compound of the series (IC50 = 385 nmol/l)."
08/15/2010 - "Whereas, H-Dmt-Tic-Asp *-Bid is a potent and selective delta agonist (MVD, IC(50)=0.12nM); H-Dft-Tic-Asp *-Bid and H-Tyr-Tic-Asp *-Bid are potent and selective delta antagonists (pA(2)=8.95 and 8.85, respectively). "
02/01/2008 - "[(3)H]Tyr-Tic-(2S,3R)-beta-MePhe-Phe-OH (where Tic: 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) with a specific radioactivity of 53.7 Ci/mmol was synthesized and characterized in receptor binding assays at 25 degrees C in rat brain membranes. "
05/01/1998 - "Two different models for the receptor-bound conformation of delta-opioid peptide antagonists containing the N-terminal dipeptide segment H-Tyr-Tic (Tic = 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) have been proposed. "
12/01/1995 - "In the present paper we investigate the influence of sample pH on the conformational and dynamical properties of the pseudotripeptide H-Tyr-Tic psi [CH2-NH]Phe-OH (TIP[psi]; Tic: 1,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid) using various one- and two-dimensional nmr techniques in conjunction with molecular modeling. "
12/01/1998 - "We propose that in this experimental respiration model, the delta antagonists naltrindole and H-Tyr-Tic(psi)[CH2NH]Phe-Phe-OH behave like delta agonists with low but sufficient intrinsic activities to reverse alfentanil-induced hypercapnia in rats. "
12/01/1998 - "In addition, intracerebroventricular delivery of a number of peptide delta ligands cyclic[D-Pen2,5]enkephalin, deltorpnin II and H-Tyr-Tic(psi)[CH2NH]Phe-Phe-OH also produced the same differential reversal of hypercapnia without affecting antinociception. "
|3.||Opioid Peptides (Opioid Peptide)
|5.||Narcotic Antagonists (Opioid Antagonists)
|9.||2',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acid
|10.||tyrosyl- 1,2,3,4- tetrahydro- 3- isoquinolinecarbonyl- phenylalanyl- phenylalanine (TIPP)