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F 4614

a mutein of tumor necrosis factor alpha (TNF-alpha); contains mutations of Thr(5) substituted by Gly, Pro(6) substituted by Asp, and Arg(29) substituted by Val; the mutations resulted in cell-adhesive Arg-Gly-Asp and reduced hypotensive effects and lower lethality
Also Known As:
F-4614; F4614
Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kawagoe, T: 1 article (10/2000)
2. Nakagawa, S: 1 article (10/2000)
3. Miyata, K: 1 article (10/2000)
4. Kuroda, K: 1 article (10/2000)
5. Fujita, F: 1 article (10/2000)
6. Tsutsumi, Y: 1 article (10/2000)
7. Koike, M: 1 article (10/2000)
8. Fujita, M: 1 article (10/2000)
9. Mitsuishi, Y: 1 article (10/2000)
10. Mayumi, T: 1 article (10/2000)

Related Diseases

1. Neoplasms (Cancer)
2. Hepatocellular Carcinoma (Hepatoma)
3. Sarcoma (Soft Tissue Sarcoma)
4. Fibrosarcoma

Related Drugs and Biologics

1. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2. Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)

Related Therapies and Procedures

1. Immunotherapy