15-deoxy-delta(12,14)-prostaglandin J2

15-deoxy-PGJ2 is also available; check for double bonds (indicated by delta) at 12 and 14 positions

Also Known As:

15-deoxy-12,14-prostaglandin J2; 15-deoxy-delta(12,14)PGJ2; 15-deoxy-delta-12,14-prostaglandin J2

Networked: 24 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins D: 1987
        Prostaglandin D2: 887
        15-deoxy-delta(12,14)-prostaglandin J2: 24
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins D: 1987
        Prostaglandin D2: 887
        15-deoxy-delta(12,14)-prostaglandin J2: 24

Experts

1.	Uchida, Koji: 2 articles (10/2005 - 06/2005)
2.	Fujimoto, Maki: 1 article (02/2021)
3.	Higuchi, Hitoshi: 1 article (02/2021)
4.	Honda-Wakasugi, Yuka: 1 article (02/2021)
5.	Maeda, Shigeru: 1 article (02/2021)
6.	Miyake, Saki: 1 article (02/2021)
7.	Miyawaki, Takuya: 1 article (02/2021)
8.	Nishioka, Yukiko: 1 article (02/2021)
9.	Yabuki-Kawase, Akiko: 1 article (02/2021)
10.	Aung, Max T: 1 article (11/2019)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 02/15/2004 - "The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure."
2.	Spinal Cord Injuries (Spinal Cord Injury) 03/01/2008 - "We show here that 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), a metabolite of prostaglandin D2 (PGD2) that has anti-inflammatory actions, given daily for the first 2 weeks after spinal cord contusion injury in mice, results in significant improvement of sensory and locomotor function. "
3.	Neoplasms (Cancer) 10/01/2004 - "In tumor xenografts, 15-deoxy-delta(12,14)-prostaglandin J2 and troglitazone synergistically improved antiangiogenic and antitumor effects of ABT510. "
4.	Inflammation (Inflammations) 06/01/2005 - "Recent studies demonstrated that cyclooxygenase-2 (COX-2) induced at the late phase of inflammation aids in the resolution of inflammation by generating 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2). " 12/15/2003 - "Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways." 02/05/2021 - "The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD2 metabolite, 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), and its receptor, peroxisome proliferator-activated receptor gamma (PPARγ). " 05/18/2001 - "PPAR-gamma ligands, both 15-deoxy-Delta(12,14)-prostaglandin J2 (15d- PGJ2) and troglitazone (TRO), can inhibit the growth of RA synoviocytes in vitro, and suppress the chronic inflammation of adjuvant-induced arthritis in rats, but the potency of 15d-PGJ2 is higher than TRO. "
5.	Thyroid Neoplasms (Thyroid Cancer) 07/01/2006 - "The aim of this study was to examine the effects of two PPARgamma agonists, ciglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 (15dPGJ2), on the survival of thyroid carcinoma CGTH W-2 cells. " 05/01/2001 - "PPARgamma-positive thyroid carcinoma cells were treated with agonists of PPARgamma, troglitazone, BRL 49653, and 15-deoxy-12,14-prostaglandin J2. "

Related Drugs and Biologics

1.	Prostaglandins
2.	cyclopentenone
3.	Prostaglandin D2
4.	Troglitazone (Rezulin)
5.	NAc- Sar- Gly- Val- (d- allo- Ile)- Thr- Nva- Ile- Arg- ProNEt (ABT 510)
6.	PPAR gamma
7.	ciglitazone
8.	Cyclooxygenase 2 (Cyclooxygenase-2)
9.	Heat-Shock Proteins (Heat-Shock Protein)
10.	carp gonadotropin