AGN 193109

structure given in first source

Also Known As:

4-((5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl)ethynyl)benzoic acid; AGN-193109; AGN193109; Benzoic acid, 4-(2-(5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl)ethynyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        AGN 193109: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - AGN 193109: 5

Experts

1.	Karperien, Marcel: 1 article (02/2006)
2.	Löwik, Clemens: 1 article (02/2006)
3.	Papapoulos, Socrates: 1 article (02/2006)
4.	van Beek, Ermond: 1 article (02/2006)
5.	Andela, Valentine B: 1 article (03/2004)
6.	Rosier, Randy N: 1 article (03/2004)
7.	Beard, R L: 1 article (12/2001)
8.	Chandraratna, R A: 1 article (12/2001)
9.	Escobar, M: 1 article (12/2001)
10.	Standeven, A M: 1 article (12/2001)

Related Diseases

1.	Hypertriglyceridemia 10/01/1996 - "Hypertriglyceridemia induced by AGN 190121 was significantly inhibited by cotreatment with an RAR-selective antagonist, AGN 193109. " 12/01/2001 - "RXR-specific retinoids, as previously reported, had no independent effect on serum triglycerides when tested at 24 hr after final dosing, but did elicit a reversible hypertriglyceridemia at 2.5 and 5 hr. This induction of serum triglycerides could not be blocked by the potent RAR-specific antagonist AGN 193109 [4-[(5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl)-ethynyl] benzoic acid]. "
2.	Weight Loss (Weight Reduction) 05/01/1996 - "TTNPB pretreatment caused precipitous weight loss and, in the absence of AGN 193109 intervention, 60% mortality. " 05/01/1996 - "TTNPB treatment alone caused cutaneous irritation and weight loss, and these effects were inhibited by AGN 193109 cotreatment. "
3.	Splenomegaly 05/01/1996 - "TTNPB caused skin flaking, skin abrasions, and splenomegaly, and these effects were blocked in a dose-dependent fashion by AGN 193109 cotreatment. "
4.	Neoplasms (Cancer) 03/22/2004 - "Using Line 1 tumor cells as a model for signal regulation of metastatic gene expression, we investigated the reciprocal interactions between NFkappaB and RARs in response to the pan-RAR agonist, all-trans retinoic acid (at-RA) and the pan-RAR antagonist, AGN193109. "
5.	Bone Resorption 02/01/2006 - "We show here that RA, GGOH, GGPP and GGA stimulate osteoclastic bone resorption and that this action is reversed by the RAR antagonist AGN-193109. "

Related Drugs and Biologics

1.	Benzoic Acid (Potassium Benzoate)
2.	Triglycerides (Triacylglycerol)
3.	Tretinoin (Retinoic Acid)
4.	Retinoids
5.	AGN 190121
6.	4- (2- (5,6,7,8- tetrahydro- 5,5,8,8- tetramethyl- 2- naphthalenyl)- 1- propenyl)benzoic acid