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FTI 277

a ras CAAX (C - Cys; A - aliphatic amino acid; X - Ser or Met) peptidomimetic; inhibits farnesyltransferase; blocks Ras oncogenic signaling by accumulating Ras/Raf complexes in the cytoplasm; structure given in first source
Also Known As:
FTI-277
Networked: 34 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Hamilton, A D: 4 articles (02/2003 - 01/2000)
2. Sebti, S M: 3 articles (02/2003 - 01/2000)
3. Kaneki, Masao: 2 articles (01/2015 - 12/2011)
4. Yamada, Marina: 2 articles (01/2015 - 12/2011)
5. Tompkins, Ronald G: 2 articles (01/2015 - 12/2011)
6. Yu, Yong-Ming: 2 articles (01/2015 - 12/2011)
7. Fischman, Alan J: 2 articles (01/2015 - 12/2011)
8. Mutoh, Junpei: 2 articles (04/2014 - 02/2008)
9. Ohsawa, Masahiro: 2 articles (04/2014 - 02/2008)
10. Hisa, Hiroaki: 2 articles (04/2014 - 02/2008)

Related Diseases

1. Colorectal Neoplasms (Colorectal Cancer)
2. Liver Neoplasms (Liver Cancer)
3. Insulin Resistance
4. Glioma (Gliomas)
5. Burns

Related Drugs and Biologics

1. Farnesyltranstransferase (Farnesyltransferase)
2. GGTI 298
3. Phosphotransferases (Kinase)
4. P-Glycoprotein
5. Protein Kinases (Protein Kinase)
6. Heat-Shock Proteins (Heat-Shock Protein)
7. GGTI 286
8. U 0126 (UO 126)
9. 17-(allylamino)-17-demethoxygeldanamycin (17AAG)
10. Transferases