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HBOC 201 (Hemopure)

a substitute agent for oxygen delivery; consists of polymerized bovine hemoglobin in a modified buffer of Ringer's lactate; contains less than 15% hemoglobin; Hemopure is tradename
Also Known As:
Hemopure; HBOC-201; hemoglobin glutamer-250; hemoglobin-based oxygen carrier-201
Networked: 98 relevant articles (12 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Freilich, Daniel: 20 articles (08/2012 - 10/2004)
2. McCarron, Richard: 17 articles (08/2012 - 10/2004)
3. Arnaud, Françoise: 13 articles (08/2012 - 10/2004)
4. Philbin, Nora: 10 articles (05/2012 - 10/2004)
5. McGwin, Gerald: 9 articles (05/2012 - 09/2005)
6. Rice, Jennifer: 9 articles (05/2012 - 10/2004)
7. Pearce, L Bruce: 9 articles (02/2009 - 07/2002)
8. Dubé, Gregory P: 7 articles (02/2020 - 03/2008)
9. Kerby, Jeffrey D: 7 articles (08/2009 - 10/2003)
10. Ahlers, Stephen: 6 articles (01/2009 - 09/2005)

Related Diseases

1. Hemorrhage
2. Hemorrhagic Shock
3. Neoplasms (Cancer)
4. Anemia
5. Multiple Trauma (Multiple Injuries)
05/01/2012 - "In this polytrauma swine model of uncontrolled haemorrhage and TBI with a 30-min delay to hospital arrival, pre-hospital resuscitation with one bolus of HBOC-201 indicated short term benefits in systemic and cerebrovascular physiological parameters. "
10/01/2008 - "We tested the hypothesis that HBOC-201 would improve cerebrovascular resuscitation in a unique polytrauma model. "
10/01/2008 - "1) A single bolus of HBOC-201 at initial resuscitation rapidly restored cerebral perfusion pressure and stabilized hemodynamics with improved intracranial pressure and brain oxygen for the first 8 hrs; and 2) HBOC-201 could be an effective salvage therapy after severe neurotrauma or as a temporizing measure during prolonged transport of a polytrauma patient."
05/01/2012 - "In a combined polytrauma model of uncontrolled haemorrhage and traumatic brain injury (TBI) in swine, we investigated if pre-hospital administration of the haemoglobin based oxygen carrier HBOC-201 will improve tissue oxygenation and physiologic parameters compared to Lactated Ringer's (LR) solution. "
05/01/2000 - "While clinical studies with human cross-linked hemoglobin (DCLHb) have been stopped last year because of the results of two clinical trials showing an increased mortality in patients with stroke and multiple injury shock being treated with DCLHb in comparison with saline, a phase III study with polymerized bovine hemoglobin HBOC-201 is actually being performed in noncardiac patients with perioperative bleeding. "

Related Drugs and Biologics

1. Oxygen (Dioxygen)
2. Hemoglobins (Hemoglobin)
3. Solutions
4. Ringer's Lactate
5. Blood Substitutes (Artificial Blood)
6. recombinant FVIIa (rFVIIa)
7. Hydroxyethyl Starch Derivatives (Pentastarch)
8. 3,4,4a,10b- tetrahydro- 4- propyl- 2H,5H- (1)benzopyrano(4,3- b)- 1,4- oxazin- 9- ol
9. 6-chloro-2-(1-piperazinyl)pyrazine (CPP)
10. HBOC 201 (Hemopure)

Related Therapies and Procedures

1. Resuscitation
2. Salvage Therapy
3. Therapeutics
4. Blood Transfusion (Blood Transfusions)
5. Cardiopulmonary Bypass (Heart-Lung Bypass)