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B 956

a farnesyl transferase inhibitor; structure given in first source

Also Known As:

B-956; B956

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Amino Acids: 221
    - Methionine: 6648
      - B 956: 3
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675

Experts

1.	Haagmans, Bart L: 1 article (07/2008)
2.	Koraka, Penelopie: 1 article (07/2008)
3.	Martina, Byron E E: 1 article (07/2008)
4.	Osterhaus, Albert D M E: 1 article (07/2008)
5.	Rimmelzwaan, Guus F: 1 article (07/2008)
6.	van den Doel, Petra: 1 article (07/2008)

Related Diseases

1.	Neoplasms (Cancer) 11/15/1995 - "Furthermore, inhibition of tumor growth by B956 is shown to be correlated with inhibition of ras posttranslational processing in the tumor. " 11/15/1995 - "Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956." 11/15/1995 - "B956/B1086 at 100 mg/kg also inhibited tumor growth by EJ-1 human bladder carcinoma, HT1080 human fibrosarcoma, and to a lesser extent by HCT116 human colon carcinoma xenografts in nude mice. " 01/01/1997 - "Methyl ester prodrug of B956 and B1352 showed antitumor activity in ras mutated human tumor xenograft model. "
2.	Infections 07/01/2008 - "Furthermore, WNV can productively infect cultured human dendritic cells (DCs) and infection of dendritic cells with the glycosylated WNV-NY99 L1 strain induced production of significantly more TNF-alpha and IFN-alpha in cultured DC, than infection with the non-glycosylated B956 L2 strain. "
3.	Fibrosarcoma 11/15/1995 - "B956/B1086 at 100 mg/kg also inhibited tumor growth by EJ-1 human bladder carcinoma, HT1080 human fibrosarcoma, and to a lesser extent by HCT116 human colon carcinoma xenografts in nude mice. "
4.	Carcinoma (Carcinomatosis) 11/15/1995 - "B956/B1086 at 100 mg/kg also inhibited tumor growth by EJ-1 human bladder carcinoma, HT1080 human fibrosarcoma, and to a lesser extent by HCT116 human colon carcinoma xenografts in nude mice. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Transferases
3.	Prodrugs
4.	Esters
5.	B1352