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arenastatin A

a potent cytotoxic depsipeptide from marine sponge, Dysidea arenaria; structure given in first source

Also Known As:

cryptophycin-24

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - arenastatin A: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - arenastatin A: 3

Experts

1.	Joshi, Penny: 1 article (08/2008)
2.	Rawat, Diwan S: 1 article (08/2008)
3.	Sharma, Mukul: 1 article (08/2008)
4.	Singh, Ram: 1 article (08/2008)
5.	Kobayashi, Motomasa: 1 article (05/2004)
6.	Koyama, Kouhei: 1 article (05/2004)
7.	Maekawa, Ryuji: 1 article (05/2004)
8.	Murakami, Nobutoshi: 1 article (05/2004)
9.	Sugimoto, Masanori: 1 article (05/2004)
10.	Tamura, Satoru: 1 article (05/2004)

Related Diseases

1.	Neoplasms (Cancer) 05/17/2004 - "Notably, 15-tert-butylanalogue (6) with higher cytotoxicity exhibited in vivo anti-tumor activity through iv administration different from 1. Additionally, conformation analysis among the two analogues and arenastatin A (1) indicated that the torsion angle from C-14 to C-20 is a conclusive factor for the potent cytotoxicity of 1." 05/17/2004 - "New analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, with anti-tumor activity." 08/01/2008 - "Didemnin was the first marine peptide that entered in human clinical trials in US for the treatment of cancer and other compounds such as dolastatin-10, soblidotin, didemnin B, ecteinascidin 743, girolline, aplidine, cryptophycins (also arenastatin A), bryostatin 1, ILX 651, kahalalide F, E7389, discodermolide, ES-285 (spisulosine), HTI-286 (hemiasterlin derivative), squalamine, KRN-7000, vitilevuamide, Laulimalide, Curacin A, diazonamide, peloruside A, eleutherobin, sarcodictyin, thiocoraline, salicylihalimides A, ascididemnin, CGX-1160, CGX-1007dictyodendrins, GTS-21 (aka DMBX), manoalide, IPL-576,092 (aka HMR-4011A) have entered in the clinical trials. "
2.	Breast Neoplasms (Breast Cancer) 01/29/2004 - "The unsubstituted, 3'-Cl, 4'-C1, and 3',4'-diCl C10 analogues of cryptophycin-24 were prepared via total synthesis and tested in vitro for cytotoxicity against MCF-7 and multi-drug-resistant MCF-7/ADR breast cancer cell lines and in a tubulin assembly assay. "

Related Drugs and Biologics

1.	Depsipeptides
2.	Peptides (Polypeptides)
3.	Trabectedin
4.	girolline
5.	tasidotin
6.	HTI-286
7.	hemiasterlin
8.	vitilevuamide
9.	peloruside A
10.	spisulosine