ICA512 autoantibody

provides a specific marker for type I diabetes

Also Known As:

IA-2 antibody; IA-2 autoantibody; IA-2-autoantibody; ICA512AA

Networked: 29 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        ICA512 autoantibody: 29
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        ICA512 autoantibody: 29
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        ICA512 autoantibody: 29

Experts

1.	Knip, Mikael: 2 articles (12/2004 - 01/2002)
2.	Scherbaum, W A: 2 articles (04/2002 - 11/2000)
3.	Schott, M: 2 articles (04/2002 - 11/2000)
4.	Seissler, J: 2 articles (04/2002 - 11/2000)
5.	Baumann, K: 1 article (01/2021)
6.	Kerner, W: 1 article (01/2021)
7.	Kesselring, K: 1 article (01/2021)
8.	Lampasona, V: 1 article (01/2021)
9.	Schlosser, M: 1 article (01/2021)
10.	Walschus, U: 1 article (01/2021)

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/01/1997 - "We confirmed that IA-2 antibody was detected in IDDM among Japanese, as seen in Caucasians, but the test sensitivity was improved only in young IDDM patients among Japanese." 01/01/2003 - "Relatives of subjects with type 1 diabetes were screened for ICA as part of the Diabetes Prevention Trial-Type 1. A total of 71,148 samples were also tested for GAA and ICA512AA. " 01/01/2000 - "Recent studies have demonstrated that a combination of GAD-antibody assays and IA-2 autoantibody assays show a high diagnostic specificity for Type 1 diabetes. " 01/01/2016 - "Type 1 diabetes may develop in the elderly, and an IA-2 antibody test may be useful for diagnosing type 1 diabetes in older patients." 12/01/2012 - "IA-2 autoantibody affinity in children at risk for type 1 diabetes."
2.	Disease Susceptibility (Diathesis) 04/01/2006 - "IgE-IA-2 antibody reactivity may be a marker of a regulatory immune response providing protection against or delaying progression to TID among IA-2 antibody-positive young children with HLA-conferred disease susceptibility."
3.	Latent Autoimmune Diabetes in Adults 04/01/2008 - "Anti-thyroid peroxidase antibody, IA-2 antibody, and fasting C-peptide levels predict beta cell failure in patients with latent autoimmune diabetes in adults (LADA)--a 5-year follow-up of the Ehime study."
4.	Type 2 Diabetes Mellitus (MODY) 03/01/1997 - "A total of two patients out of 121 patients with NIDDM were positive for GADAA, and two other NIDDM patients, who were suffering from sarcoidosis, were positive for ICA512AA. " 04/01/2005 - "IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)." 12/01/2001 - "We report on the humoral autoimmunity to an alternatively-spliced variant of IA-2 (IA-2 variant) and autoimmune-mediated diabetes age of onset association with IA-2 autoantibody epitope specificities, in 144 recent-onset patients with type 1 diabetes and 54 GAD autoantibody-positive patients with type 2 diabetes. "
5.	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 05/25/2023 - "In the entire cohort, after adjustment for confounders, diabetes type was unknown in 62 youth (3%), associated with older age, negative IA-2 autoantibody, lower C-peptide, and no diabetic ketoacidosis (all, p<0.05). "

Related Drugs and Biologics

1.	Antibodies
2.	Biomarkers (Surrogate Marker)
3.	Autoantibodies
4.	Epitopes
5.	Insulin (Novolin)
6.	C-Peptide
7.	Class 8 Receptor-Like Protein Tyrosine Phosphatases
8.	Protein Tyrosine Phosphatases
9.	Iodide Peroxidase (Deiodinase)
10.	Autoantigens