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carboplatin-DNA adduct

Also Known As:

DNA-carboplatin adduct

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Coordination Complexes: 576
  - Carboplatin: 10368
    - carboplatin-DNA adduct: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - DNA: 145982
    - DNA Adducts: 2237
      - carboplatin-DNA adduct: 4
Genetic Phenomena
- DNA Damage
  - DNA Adducts: 2237
    - carboplatin-DNA adduct: 4

Experts

1.	Alharthi, Afaf: 1 article (01/2022)
2.	Alrehaili, Amani A: 1 article (01/2022)
3.	Gamal-Eldeen, Amira M: 1 article (01/2022)
4.	Raafat, Bassem M: 1 article (01/2022)
5.	Boddy, Alan V: 1 article (01/2012)
6.	Edmondson, Richard J: 1 article (01/2012)
7.	Jarvis, Ian W H: 1 article (01/2012)
8.	Meczes, Emma L: 1 article (01/2012)
9.	Ottley, Christopher J: 1 article (01/2012)
10.	Pearson, D Graham: 1 article (01/2012)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2012 - "We have determined carboplatin-DNA adduct levels in biopsies removed from ovarian cancer patients following treatment. "
2.	Lung Neoplasms (Lung Cancer) 01/01/2022 - "In conclusion, Perftoran® inhibited resistance of lung cancer cells to carboplatin through the inhibition of both hypoxia pathway mediators and the drug resistance transporter MRP-2 and through the induction of DNA/carboplatin adduct formation."
3.	Urinary Bladder Neoplasms (Bladder Cancer) 05/01/2006 - "We report the use of accelerator mass spectrometry (AMS), a sensitive detection method often used for radiocarbon quantitation, to measure both the kinetics of [14C]carboplatin-DNA adduct formation with genomic DNA and drug uptake and DNA binding in T24 human bladder cancer cells. "
4.	Hypoxia (Hypoxemia) 01/01/2022 - "In conclusion, Perftoran® inhibited resistance of lung cancer cells to carboplatin through the inhibition of both hypoxia pathway mediators and the drug resistance transporter MRP-2 and through the induction of DNA/carboplatin adduct formation."
5.	Hyperthermia 03/01/1992 - "Carboplatin-DNA adduct formation and cytotoxicity, however, were already increased at temperatures of about 40 degrees C, indicating that carboplatin-DNA adduct formation and consequently cytotoxicity could be enhanced by mild hyperthermia (temperatures in the range of 39-41.5 degrees C). "

Related Drugs and Biologics

1.	Carboplatin (JM8)
2.	DNA (Deoxyribonucleic Acid)