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kukoamine A

inhibits Crithidia fasciculata trypanothione reductase; structure given in first source

Also Known As:

N(1),N(12)-bis(dihydrocaffeoyl)spermine

Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Spermine: 1076
      - kukoamine A: 15
  - Biogenic Amines: 992
    - Biogenic Polyamines: 11
      - Putrescine: 919
        Spermidine: 1153
        Spermine: 1076
        kukoamine A: 15

Experts

1.	Meng, Weihong: 3 articles (07/2017 - 10/2016)
2.	Zhao, Qingchun: 3 articles (07/2017 - 10/2016)
3.	Zhang, Qiao: 2 articles (07/2017 - 01/2017)
4.	Cheng, Zhihua: 2 articles (01/2017 - 10/2016)
5.	Zhang, Yaqiong: 2 articles (01/2017 - 10/2016)
6.	Bunn, Barry J: 1 article (01/2022)
7.	Butts, Christine A: 1 article (01/2022)
8.	Cai, Xianhua: 1 article (01/2022)
9.	Dinnan, Hannah: 1 article (01/2022)
10.	Hedderley, Duncan I: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2017 - "Our previous study demonstrated Kukoamine A to exhibit strong neuroprotective effects through anti-oxidative stress, anti-inflammation, anti-excitoxicity. " 01/01/2022 - "Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway." 01/01/2022 - "The aim of this study was to elucidate the mechanism underlying the effects of Kukoamine A (KuA) treatment on endotoxin-induced lung injury/inflammation. " 11/01/2023 - "Kukoamine A protects mice against osteoarthritis by inhibiting chondrocyte inflammation and ferroptosis via SIRT1/GPX4 signaling pathway."
2.	Lung Injury 01/01/2022 - "The aim of this study was to elucidate the mechanism underlying the effects of Kukoamine A (KuA) treatment on endotoxin-induced lung injury/inflammation. " 01/01/2022 - "Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury."
3.	Hypertension (High Blood Pressure) 01/01/2022 - "Prior to the hypertension study, we determined the safety of the synthetic kukoamine A in a single oral dose (5 or 10 mg kg-1 bodyweight) 14-day observational study in mice. " 01/01/2022 - "We observed no effect of orally administered synthetic kukoamine A on arterial hypertension in this laboratory animal model of hypertension." 01/01/2022 - "We subsequently investigated the effect of daily oral doses of kukoamine A (0, 5, 10 mg kg-1 bodyweight) for 35 days using the SHR rat model of hypertension. " 01/01/2022 - "Influence of oral administration of kukoamine A on blood pressure in a rat hypertension model." 01/01/2022 - "Kukoamines, caffeic acid derivatives of polyamines present in solanaceous plants, have been reported to reduce BP. We investigated the effect of orally administered synthetic kukoamine A on BP in the Spontaneously Hypertensive Rat (SHR) laboratory animal model of hypertension. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 09/09/2022 - "ERRATA: Kukoamine A activates Akt/GSK-3β signaling pathway to inhibit oxidative stress and relieve myocardial ischemia-reperfusion injury." 01/01/2022 - "Kukoamine A activates Akt/GSK-3β signaling pathway to inhibit oxidative stress and relieve myocardial ischemia-reperfusion injury."
5.	Reperfusion Injury 09/09/2022 - "ERRATA: Kukoamine A activates Akt/GSK-3β signaling pathway to inhibit oxidative stress and relieve myocardial ischemia-reperfusion injury." 01/01/2022 - "Kukoamine A activates Akt/GSK-3β signaling pathway to inhibit oxidative stress and relieve myocardial ischemia-reperfusion injury."

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	Endotoxins
3.	Lipopolysaccharides
4.	Sirtuin 1
5.	Sterol Regulatory Element Binding Protein 1
6.	Chemokine Receptors
7.	Transcription Factor AP-1 (Transcription Factor AP 1)
8.	Polyamines
9.	Antioxidants
10.	superoxide dismutase 2

Related Therapies and Procedures

1.	Oral Administration