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JM 34

inhibits PGE2 production without directly inhibiting cyclooxygenase

Also Known As:

JM-34; JM34

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Carbonnelle, Delphine: 1 article (02/2005)
2.	Ebstein, Frederic: 1 article (02/2005)
3.	Gregoire, Marc: 1 article (02/2005)
4.	Lang, François: 1 article (02/2005)
5.	Petit, Jean-Yves: 1 article (02/2005)
6.	Rabu, Catherine: 1 article (02/2005)
7.	Bobin-Dubigeon, C: 1 article (11/2001)
8.	Collin, X: 1 article (11/2001)
9.	Grimaud, N: 1 article (11/2001)
10.	Le Baut, G: 1 article (11/2001)

Related Diseases

1.	Inflammation (Inflammations) 11/09/2001 - "The present study assessed the effect of chronic oral gavage of two in vitro TNF-alpha synthesis inhibitors, JM 34 maleate or [N-(4,6-dimethylpyridin-2-yl)-furane-2-carboxamide)] maleate and XC 21 or (N-betapicolyl-tetrafluorophtalimide), on colonic inflammation in trinitrobenzene sulphonic acid-induced colitis in rats. "
2.	Colitis 11/09/2001 - "JM 34 maleate failed to improve the clinical signs of chronic colitis. " 11/09/2001 - "Rats received JM 34 maleate (100 mg/kg) and XC 21 (50 mg/kg) 1 h before colitis induction and then daily for 8 days by oral gavage. " 11/09/2001 - "The present study assessed the effect of chronic oral gavage of two in vitro TNF-alpha synthesis inhibitors, JM 34 maleate or [N-(4,6-dimethylpyridin-2-yl)-furane-2-carboxamide)] maleate and XC 21 or (N-betapicolyl-tetrafluorophtalimide), on colonic inflammation in trinitrobenzene sulphonic acid-induced colitis in rats. "
3.	Hypersensitivity (Allergy) 02/01/2005 - "Finally, JM34 inhibited delayed type hypersensitivity dose dependently in mice. "
4.	Autoimmune Diseases (Autoimmune Disease) 02/01/2005 - "In conclusion, our data suggest that JM34 inhibited T lymphocyte activation mainly by targeting DC, and thus may represent a new class of therapeutic agents in the fields of transplantation and autoimmune diseases."

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Acids
3.	maleic acid (maleate)

Related Therapies and Procedures

1.	Transplantation