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marchantin A

16 carbon macrocyclic bis-ether bis-bibenzyl similar to riccardin A; from liverwort Marchantia polymorpha; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Bibenzyls: 16
        marchantin A: 4
- Ethers: 242
  - Cyclic Ethers: 12
    - marchantin A: 4
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Ethers: 12
    - marchantin A: 4

Experts

1.	Asakawa, Yoshinori: 2 articles (04/2020 - 01/2011)
2.	Ilic-Tomic, Tatjana: 1 article (04/2020)
3.	Koračak, Ljiljana: 1 article (04/2020)
4.	Nikodinovic-Runic, Jasmina: 1 article (04/2020)
5.	Novakovic, Miroslav: 1 article (04/2020)
6.	Opsenica, Igor: 1 article (04/2020)
7.	Simić, Stefan: 1 article (04/2020)
8.	Zlatović, Mario: 1 article (04/2020)
9.	Jensen, J Sophie: 1 article (03/2012)
10.	Ogmundsdottir, Helga M: 1 article (03/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 03/01/2012 - "polymorpha species produces marchantin A and through an in vitro cell growth inhibition assay, marchantin A was shown to induce a reduction in cell viability of breast cancer cell lines A256 (IC₅₀ = 5.5 µM), MCF7 (IC₅₀ = 11.5 µM), and T47D (IC₅₀ = 15.3 µM). " 05/01/2010 - "We found that marchantin A efficiently induced cell growth inhibition in human MCF-7 breast cancer cells, with an IC(50) of 4.0microg/mL. Fluorescence microscopy and a Western blot analysis indicated that marchantin A actively induced apoptosis of MCF-7 cells. " 04/01/2020 - "The antiproliferative activities of all prepared derivatives of marchantin A were tested on MRC-5 healthy human lung fibroblast, A549 human lung cancer, and MDA-MB-231 human breast cancer cell lines. " 03/01/2012 - "Synergistic cytotoxic effect of the microtubule inhibitor marchantin A from Marchantia polymorpha and the Aurora kinase inhibitor MLN8237 on breast cancer cells in vitro."
2.	Lung Neoplasms (Lung Cancer) 04/01/2020 - "ME3 was also the most active among all derivatives against lung cancer cells A549 with the slightly lower activity and selectivity in comparison to marchantin A." 04/01/2020 - "The antiproliferative activities of all prepared derivatives of marchantin A were tested on MRC-5 healthy human lung fibroblast, A549 human lung cancer, and MDA-MB-231 human breast cancer cell lines. "
3.	Human Influenza (Influenza) 01/01/2011 - "In a cultured cell system, marchantin E was further found to inhibit the growth of both H3N2 and H1N1 influenza A viruses, and marchantin A, E and perrotein F showed inhibitory properties towards the growth of influenza B. " 01/01/2011 - "We found from our screen that marchantin A, B, E, plagiochin A and perrottetin F inhibit influenza PA endonuclease activity in vitro. "

Related Drugs and Biologics

1.	Aurora Kinases
2.	Endonucleases
3.	MLN 8237