Staphylococcus aureus RNAIII

a 510 nucleotide, regulatory RNA molecule that controls the synthesis of virulence factors in Staphylococcus aureus encoded by the agr locus including an mRNA coding for delta-hemolysin

Also Known As:

Networked: 28 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seidl, Kati: 3 articles (01/2019 - 12/2011)
2.	Xiong, Yan Q: 3 articles (01/2019 - 12/2011)
3.	Bayer, Arnold S: 3 articles (05/2015 - 09/2002)
4.	Donnio, Pierre-Yves: 2 articles (01/2021 - 01/2016)
5.	Felden, Brice: 2 articles (01/2021 - 01/2016)
6.	Abdelhady, Wessam: 2 articles (01/2019 - 05/2015)
7.	Cheung, Ambrose: 2 articles (01/2019 - 02/2012)
8.	Chen, Liang: 2 articles (05/2015 - 12/2011)
9.	Kreiswirth, Barry N: 2 articles (05/2015 - 12/2011)
10.	Yeaman, Michael R: 2 articles (05/2015 - 09/2002)

Related Diseases

1.	Staphylococcal Infections 05/01/2008 - "In Staphylococcus aureus, the target of RNAIII activating protein (TRAP) is a membrane-associated protein whose C-terminus can be used as a vaccine to provide protection against staphylococcal infection. "
2.	Infections 01/01/2021 - "The expression profiles of the tested sRNAs were distinct and they fluctuated over time, with expression of both sprD and sprC increased during infection and associated with mortality, while rnaIII expression remained barely detectable over time. " 09/01/2014 - "Moreover, we found that RNAIII, the effector of agr system, was essential for the intracranial infection caused by S. " 02/01/2014 - "Furthermore, the sasX gene might be related to the expressions of PSMα and RNAIII and infection invasiveness." 01/15/2008 - "Furthermore, ST151 had elevated levels of RNAIII and cytolytic toxin-gene expression, consistent with the enhanced virulence observed during experimental infection. " 06/01/2001 - "As with RNAIII, the highest hla expression was detected in both strains early in infection. "
3.	Septic Shock (Toxic Shock Syndrome) 01/01/2016 - "Expression of RNAIII was lower in strains from septic shock patients than in strains from colonized patients. " 01/01/2016 - "When RNAIII was associated with expression of sprD, colonizing strains could be discriminated from strains in patients with bloodstream infections, including patients with sepsis and septic shock. " 11/01/2010 - "In the present study, we have examined the role of both SarA and RNAIII on the regulation of the promoter of tst, encoding staphylococcal superantigen toxic shock syndrome toxin 1 (TSST-1). " 02/01/2002 - "Expression of RNAIII, the effector molecule of the agr locus, was dramatically repressed in serum and in vivo, despite the increased expression of secreted virulence factors sufficient to cause toxic shock syndrome (TSS) in the animals. " 04/01/2004 - "This system down-regulates production of agr RNAIII, protein A, and toxic shock syndrome toxin 1 (TSST-1), particularly under low-oxygen conditions. "
4.	Endocarditis 01/01/2022 - "Vegetation Formation in Staphylococcus Aureus Endocarditis Inversely Correlates With RNAIII and sarA Expression in Invasive Clonal Complex 5 Isolates." 09/01/2002 - "In experimental endocarditis, maximal RNAII activation in vegetations occurred early, followed by progressive increases in RNAIII activation (P<.05; 2 vs. 48 h); this paralleled significant increases in vegetation bacterial densities over time (P<.05; 2 and 6 vs. 48 h). " 09/01/2002 - "Activation and transcriptional interaction between agr RNAII and RNAIII in Staphylococcus aureus in vitro and in an experimental endocarditis model." 12/01/2011 - "aureus (MRSA) bloodstream isolates (5 agr-I [clonal complex 45, or CC45] and 5 agr-II [CC5]) were studied for (i) agr function, (ii) RNAIII transcriptional profiles, (iii) agr locus sequences, (iv) intrinsic virulence and responses to vancomycin therapy in an experimental infective endocarditis (IE) model, and (v) in vivo RNAIII expression. " 04/01/2004 - "Overexpression of SrrAB, which represses agr RNAIII, TSST-1, and protein A in vitro, decreases virulence in the rabbit endocarditis model. "
5.	Sepsis (Septicemia) 01/01/2022 - "Thus, RNAIII and sarA expression that provides for rheostat control of colonization and virulence genes, rather than an on and off switch, promote both vegetation formation and lethal sepsis." 01/01/2016 - "Monitoring expression of RNAIII and sprD could help determine severity of bloodstream infections." 01/01/2016 - "When RNAIII was associated with expression of sprD, colonizing strains could be discriminated from strains in patients with bloodstream infections, including patients with sepsis and septic shock. " 02/01/2015 - "RIP-V improves murine survival in a sepsis model by down-regulating RNAIII expression and α-hemolysin release of methicillin-resistant Staphylococcus aureus."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Vaccines
3.	Membrane Proteins (Integral Membrane Proteins)
4.	Superantigens
5.	Peptides (Polypeptides)
6.	Virulence Factors (Pathogenicity Factors)
7.	Biomarkers (Surrogate Marker)
8.	Vancomycin
9.	Staphylococcal Protein A (Protein A)
10.	16S Ribosomal RNA

Related Therapies and Procedures

1.	Therapeutics