2- (2- nitro- 1H- imidazol- 1- yl)- N- (2,2,3,3,3- pentafluoropropyl)acetamide

a pentafluorinated derivative of etanidazole

Also Known As:

2-nitro-N-(2,2,3,3,3-pentafluoropropyl)-1H-imidazole-1-acetamide; 2-nitroimidazole EF5; EF5 compound; compound EF5

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - Fluorocarbons: 1209
        2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide: 13
- Nitro Compounds: 66
  - Nitroimidazoles: 565
    - Etanidazole: 123
      - 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide: 13
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Nitroimidazoles: 565
        Etanidazole: 123
        2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide: 13

Experts

1.	Koch, Cameron J: 3 articles (03/2015 - 04/2003)
2.	Chang, Qing: 1 article (03/2015)
3.	Chaudary, Naz: 1 article (03/2015)
4.	Hedley, David W: 1 article (03/2015)
5.	Hill, Richard P: 1 article (03/2015)
6.	Marie-Egyptienne, Delphine T: 1 article (03/2015)
7.	Ornatsky, Olga I: 1 article (03/2015)
8.	Tanner, Scott D: 1 article (03/2015)
9.	Foehrenbacher, Annika: 1 article (03/2012)
10.	Hay, Michael P: 1 article (03/2012)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/1997 - "Immunohistochemical detection of the 2-nitroimidazole EF5 was performed to determine the presence and level of hypoxia in the biopsy samples. " 10/01/2001 - "We evaluated the levels and distribution of hypoxia in 31 human tumors using fluorescent immunohistochemical detection of binding by the 2-nitroimidazole, EF5. " 01/01/1999 - "Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia-ischemia." 03/01/2006 - "Accordingly, no indication for tissue hypoxia in this central area was detected with 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide staining and VEGF expression as hypoxic markers. " 04/01/1999 - "Labeling with the compound EF5 in a normal PM indicated no segmental hypoxia; this argued that oxygen deprivation was unlikely to be the cause of synchronous apoptosis. "
2.	Neoplasms (Cancer) 12/01/2008 - "We studied the relationship between tumor vasculature and regions of low pO(2) using quantitative analysis of binding of the 2-nitroimidazole EF5 given to patients intravenously (21 mg/kg) approximately 24 h preceding surgery. " 04/01/2003 - "In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors." 10/01/2001 - "We evaluated the levels and distribution of hypoxia in 31 human tumors using fluorescent immunohistochemical detection of binding by the 2-nitroimidazole, EF5. " 07/15/2005 - "Immunofluorescent analysis of tumor sections and quantitative assessment with flow cytometry indicate colocalization between beta-hCG and 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide (EF5) and beta-hCG and pimonidazole, two extrinsic markers for tumor hypoxia. " 01/01/1997 - "In this paper, we demonstrate the qualitative and quantitative presence of hypoxic tumor cells using the oxygen dependent metabolism of the 2-nitroimidazole, EF5. "
3.	Ischemia 01/01/1999 - "Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia-ischemia."

Related Drugs and Biologics

1.	Oxygen (Dioxygen)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Biomarkers (Surrogate Marker)
4.	Prodrugs
5.	Oxidoreductases (Dehydrogenase)
6.	DNA (Deoxyribonucleic Acid)
7.	Cisplatin (Platino)
8.	Monoclonal Antibodies
9.	CEN-209
10.	pimonidazole