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hemoglobin Hakkari

leucine replaced by arginine at position B13 on alpha2,beta2 chains

Also Known As:

Hb Hakkari

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Hakkari: 3
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Hakkari: 3

Experts

1.	Dunbar, Levette N: 1 article (11/2014)
2.	Eldjerou, Lamis K: 1 article (11/2014)
3.	Harris, Neil S: 1 article (11/2014)
4.	Nair, Sushmita: 1 article (11/2014)
5.	Azimi, M: 1 article (02/2010)
6.	Guo, H: 1 article (02/2010)
7.	Hazard, F K: 1 article (02/2010)
8.	Kanathezhath, B: 1 article (02/2010)
9.	Kidd, J: 1 article (02/2010)
10.	Kuypers, F A: 1 article (02/2010)

Related Diseases

1.	beta-Thalassemia (Cooley's Anemia) 02/01/2010 - "Hemoglobin Hakkari: an autosomal dominant form of beta thalassemia with inclusion bodies arising from de novo mutation in exon 2 of beta globin gene." 02/01/2010 - "While most such patients have thalassemia intermedia, we describe a young Guatemalan child with a de novo mutation in the beta globin gene, codon 31 T --> G (Hemoglobin Hakkari), who developed severe anemia at the age of 10 months and remains transfusion-dependent. "
2.	Thalassemia 11/01/2014 - "Rare form of autosomal dominant thalassemia--hemoglobin Hakkari." 11/01/2014 - "We describe a case of Hemoglobin Hakkari, a rare variant of dominant Thalassemia arising due to a de novo mutation in the exon 2 of the beta globin gene."
3.	Hyperplasia 05/01/1995 - "Hb Hakkari or alpha 2 beta 2 31(B13)Leu-->Arg, a severely unstable hemoglobin variant associated with numerous intra-erythroblastic inclusions and erythroid hyperplasia of the bone marrow."
4.	Hemolytic Anemia 05/01/1995 - "A severely unstable hemoglobin variant, Hb Hakkari or alpha 2 beta 2 31 (B13)Leu-->Arg, has been observed in a 5-year-old Turkish girl with a severe hemolytic anemia without Heinz body formation. "
5.	Anemia 02/01/2010 - "While most such patients have thalassemia intermedia, we describe a young Guatemalan child with a de novo mutation in the beta globin gene, codon 31 T --> G (Hemoglobin Hakkari), who developed severe anemia at the age of 10 months and remains transfusion-dependent. "

Related Drugs and Biologics

1.	beta-Globins (beta Globin)
2.	Hemoglobins (Hemoglobin)
3.	Codon (Codons)
4.	leucylarginine