RN given refers to compound with no isomeric designation
Also Known As:
O-methylserine, (D)-isomer; O-methylserine, (DL)-isomer; O-methylserine, (L)-isomer
relevant articles (0 outcomes,
Bio-Agent Context: Research Results
|1. ||Ganglion Cysts (Ganglion)
- "[1-N-methylisoleucine,8-threonine]-(I), [1-dimethylglycine,8-threonine]-(II), [1-guanidineacetic acid,8-threonine]-(III), des-1-aspartic acid-[8-threonine]-(IV), and [1-sarcosine,8-O-methylserine]angiotensin II (V) were synthesized by Merrifield's solid-phase procedure to study the effect of (a) substituents in position 1 on the antagonistic activity of [1-sarcosine,8-threonine]angiotensin II, and (b) a change in size and branching in position 8 of [1-sarcosine,-8-O-methylthreonine]angiotensin II. The analogues I-V caused an initial rise in blood pressure (30 min of infusion, 250 ng/kg/min in vagotomized ganglion-blocked rats) of 8.05, 11.7, 3.50, 4.5, and 11.16 mmHg.
Related Drugs and Biologics