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neltenexine

elastase inhibitor; may be useful for preventing pulmonary emphysema

Also Known As:

(4-(2-tenoyl)amino-3,5-dibromophenylmethyl)aminocyclohexanol hydrochloride

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Bromhexine: 142
      - Ambroxol: 378
        neltenexine: 4
  - Cyclohexylamines: 33
    - Bromhexine: 142
      - Ambroxol: 378
        neltenexine: 4

Experts

1.	Hasegawa, Isao: 1 article (05/2007)
2.	Iwasaki, Yoshinobu: 1 article (05/2007)
3.	Marunaka, Yoshinori: 1 article (05/2007)
4.	Miyazaki, Hiroaki: 1 article (05/2007)
5.	Nakajima, Ken-ichi: 1 article (05/2007)
6.	Niisato, Naomi: 1 article (05/2007)
7.	Taruno, Akiyuki: 1 article (05/2007)
8.	Tokuda, Shinsaku: 1 article (05/2007)
9.	Cattaneo, C: 1 article (08/2001)
10.	Fadda, G: 1 article (08/2001)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 08/01/2001 - "The study confirmed earlier clinical experiences showing that neltenexine is effective in the treatment of COPD patients and highlighted the correlation between abstention from smoking and the efficacy of mucoactive treatment." 08/01/2001 - "The aim of this double-blind, randomised, controlled study vs placebo was to evaluate the efficacy and tolerability of neltenexine (tablets) versus placebo (tablets), administered to smoking and non-smoking patients with chronic obstructive pulmonary disease (COPD). " 08/01/2001 - "Neltenexine tablets in smoking and non-smoking patients with COPD. " 05/18/2007 - "Neltenexine has been applied to human lung diseases such as chronic obstructive pulmonary disease (COPD) as a mucolytic agent. "
2.	Emphysema 01/01/1995 - "Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats."
3.	Cough 08/01/2001 - "At the study end, the improvement of patients treated with neltenexine (smokers and non-smokers) was greater and statistically significant as compared with the patients in the placebo group in terms of improvement of dyspnoea (p<0.02), cough (p<0.02), pulmonary auscultation (p<0.02), and difficulty in expectorating (p<0.02). "
4.	Tuberculosis (Tuberculoses) 08/01/2001 - "The exclusion criteria were allergy to neltenexine or sobrerol, an assessed diagnosis of severe bronchospasm requiring beta2-agonists, corticosteroids or aminophylline, pregnant or nursing women, cystic fibrosis, active tuberculosis or an assessed diagnosis of bronchiectasis. "
5.	Pulmonary Emphysema 01/01/1995 - "These experimental findings suggest that neltenexine might prove to be useful for preventing pulmonary emphysema. "

Related Drugs and Biologics

1.	Pancreatic Elastase (Elastase)
2.	Tablets
3.	Expectorants (Mucolytics)
4.	Aminophylline (Carine)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	sobrerol