SB 203347

an inhibitor of 14-kDa phospholipase A2; structure given in first source (name/structure DISCREPANCY - trifluoromethylphenoxy- vs. trifluoromethylphenylmethyl-)

Also Known As:

2-(2-(3,5-bis(trifluoromethyl)benzenesulfonamido)-4-trifluoromethylphenoxy)benzoic acid; SB-203347

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - SB 203347: 2
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - SB 203347: 2

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 09/01/1995 - "Finally, SB 203347 prolonged survival in a mouse model of endotoxin shock delivered i.p. " 09/01/1995 - "SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock."
2.	Granuloma 05/20/1998 - "SB 203347 reduced both LTB4 and PAF, but not PGD2 levels measured in the day 6 granuloma. " 05/20/1998 - "Therefore, SB 203347, an inhibitor of the 14 kDa PLA2, zileuton, an inhibitor of 5-lipoxygenase, and Ro 24-4736 a PAF receptor antagonist were evaluated for their effects in the murine air pouch granuloma. "

Related Drugs and Biologics

1.	Phospholipases A2 (Phospholipase A2)
2.	Arachidonic Acid (Vitamin F)
3.	Prostaglandin D2
4.	Leukotriene B4
5.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
6.	Ro 24-4736
7.	zileuton (Zyflo)