|1.||Legos, Jeffrey J: 1 article (05/2002)|
|2.||Leshley, Karin: 1 article (05/2002)|
|3.||Gritman, Kurt R: 1 article (05/2002)|
|4.||Tuma, Ronald F: 1 article (05/2002)|
|5.||Sands, Howard: 1 article (05/2002)|
|6.||Weaver, Michael: 1 article (05/2002)|
|2.||Brain Ischemia (Cerebral Ischemia)
05/01/2002 - "Focal cerebral ischemia in the rat was produced by intravascular occlusion of the middle cerebral artery for a period of 30 min. Just prior to thread withdrawal (i.e., reperfusion), rats received an iv bolus administration of either vehicle or LEX032 (50 mg/kg), an optimal dose chosen based on previous studies. "
05/01/1997 - "LEX 032, a genetically engineered recombinant human nonglycosylated serpin, has been shown to have antiinflammatory properties in a number of animal models of inflammation and reperfusion injury. "
05/01/2002 - "This data demonstrates that LEX032 reduces brain injury and suggests that serine protease inhibitors may reduce ischemia/reperfusion injury by decreasing leukocyte activation and migration."
05/01/2002 - "On a scale ranging from 0 to 3, with three indicating the most severely injured, the LEX032 animals had a significantly better neurologic score (1.0 +/- 0.9) than the untreated animals (2.3 +/- 0.5) 24 h after ischemia. "
05/01/2002 - "LEX032, a novel recombinant serpin, protects the brain after transient focal ischemia."
08/01/1999 - "Twenty-eight anesthetized rats received either Lex032 or NaCl 0.9% as a control solution during baseline conditions or after 1 h of complete reversible ischemia induced by microclip occlusion of the pancreatic arteries. "
05/01/2002 - "This investigation examined the effectiveness of a serine protease inhibitor (LEX032) when used as a cerebral protective agent after ischemia. "
08/01/1999 - "Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary no-reflow in ischemia/reperfusion-induced acute pancreatitis."
|5.||Wounds and Injuries (Trauma)
10/01/1995 - "Moreover, administration of LEX032 significantly preserved superior mesenteric artery (SMA) endothelial function as measured by the relaxation response of isolated (SMA) rings to acetylcholine, an endothelium-dependent vasodilator (64 +/- 10% vs. 25 +/- 6%, p < .01 compared with untreated trauma rats). "
|1.||Serine Proteases (Serine Protease)
|3.||Serine Proteinase Inhibitors (Serine Protease Inhibitors)
|4.||Peptide Hydrolases (Proteases)
|5.||Pancreatic Elastase (Elastase)
|7.||Acetylcholine (Acetylcholine Chloride)