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serralysin

zinc metalloproteinases with broad similar specificity for cleavage of the oxidized insulin B chain

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        serralysin: 9
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        serralysin: 9

Experts

1.	Amin, Mohsen: 1 article (08/2019)
2.	Araghi, Almas: 1 article (08/2019)
3.	Faramarzi, Mohammad Ali: 1 article (08/2019)
4.	Hashemi, Saba: 1 article (08/2019)
5.	Sepahi, Abbas Akhavan: 1 article (08/2019)
6.	Hao, Jianhua: 1 article (05/2017)
7.	Li, Shangyong: 1 article (05/2017)
8.	Lin, Shengxiang: 1 article (05/2017)
9.	Liu, Junzhong: 1 article (05/2017)
10.	Ma, Zibin: 1 article (05/2017)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2019 - "Purification and study of anti-cancer effects of Serratia marcescens serralysin."
2.	Infections 11/17/2022 - "We further investigated the phenotypic consequences of two classes of genes with altered expression in the ΔgumB mutant expected to contribute to infections: serralysin metalloproteases PrtS, SlpB, and SlpE, and type I pili coded by fimABCD. " 05/01/2017 - "The metalloproteinase MP belongs to the serralysin family, which is involved in important functions such as nutrient acquisition and infection pathogenesis. " 01/01/2015 - "The serralysin family of bacterial metalloproteases is associated with virulence in multiple modes of infection. " 01/01/2007 - "The Serratia marcescens-derived protease serralysin is considered to play an important role in the pathogenesis of infection. "
3.	Neuroblastoma 03/03/2023 - "The serralysin-like protein was toxic against CHP-212 (neuroblastoma), SiHa (human cervical carcinoma) and D-54 (human glioblastoma) cell lines in a dose-dependent manner and showed no cytotoxic activity in primary cultures of normal non-cancerous human keratinocytes and fibroblasts. "
4.	Mouth Diseases (Mouth Disease) 12/01/2003 - "Yersinia ruckeri, the etiological agent of the enteric red mouth disease (ERM) of salmonids, produces Yrp1, a serralysin metalloprotease involved in pathogenesis. "
5.	Hemorrhage 03/01/2014 - "Using a bioassay with live silkworms, we purified Serralysin, a metalloprotease that requires divalent cations for its activity, as the factor responsible for the promotion of hemolymph bleeding from the culture supernatant of S. "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Interleukin-8 (Interleukin 8)
3.	Interleukin-6 (Interleukin 6)
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Peptide Hydrolases (Proteases)
7.	Divalent Cations