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meprin B

a heterodimer of alpha- and beta-subunits; amino acid sequence has been determined

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        meprin B: 3
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        meprin B: 3

Experts

1.	Banerjee, Sanjita: 1 article (02/2011)
2.	Bond, Judith S: 1 article (02/2011)
3.	Bradley, S Gaylen: 1 article (02/2011)
4.	Crisman, Jacqueline M: 1 article (02/2011)
5.	Gailey, Ryan D: 1 article (02/2011)
6.	Jin, Ge: 1 article (02/2011)
7.	Matters, Gail L: 1 article (02/2011)
8.	Hirasawa, Yasushi: 1 article (04/2008)
9.	Ishii, Aiko: 1 article (04/2008)
10.	Ito, Masayoshi: 1 article (04/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1999 - "Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells."
2.	Inflammation (Inflammations) 02/01/2011 - "The data indicate that the absence of meprin A aggravates chronic inflammation and the lack of meprin B affords some protection from injury. "
3.	Glomerulonephritis 04/09/2008 - "As meprinbeta is a subunit of metalloproteinase meprins (meprin A, meprin B) and meprins are capable of proteolytically degrading extracellular matrix (ECM) components and proteolytically processing bioactive peptides, the downregulation of meprinbeta may contribute to the progression of glomerulonephritis and the eventual glomerular scarring. "
4.	Cicatrix (Scar) 04/09/2008 - "As meprinbeta is a subunit of metalloproteinase meprins (meprin A, meprin B) and meprins are capable of proteolytically degrading extracellular matrix (ECM) components and proteolytically processing bioactive peptides, the downregulation of meprinbeta may contribute to the progression of glomerulonephritis and the eventual glomerular scarring. "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	meprin A
3.	Peptides (Polypeptides)
4.	Tiopronin (Thiola)