chan su (ChanSu)

a toad glandular secretory product; contains bufadienolides which comprise mainly bufalin, cinobufagin, and resibufogenin; a major component of the traditional Chinese medicine liu-shen-wan

Also Known As:

Networked: 138 relevant articles (6 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Dong-Mei: 6 articles (02/2021 - 10/2012)
2.	Ye, Wen-Cai: 5 articles (02/2021 - 10/2012)
3.	Dasgupta, Amitava: 5 articles (04/2003 - 10/2002)
4.	Deng, Li-Juan: 4 articles (02/2021 - 08/2014)
5.	Tian, Hai-Yan: 4 articles (02/2021 - 10/2012)
6.	Wang, Xun: 4 articles (01/2020 - 11/2016)
7.	Zhang, Bo: 4 articles (01/2020 - 10/2012)
8.	Chung, Jing-Gung: 4 articles (01/2019 - 01/2014)
9.	Ma, Xiaochi: 4 articles (07/2018 - 08/2014)
10.	Liu, Yunpeng: 4 articles (09/2015 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2019 - "Previous studies show that active components in Chan Su can inhibit the proliferation of tumor cells. " 11/19/2018 - "In this study, an MSF based on single quadrupole mass spectrometry method was established, and was successfully used for the quality control of Venenum bufonis (VB), a famous TCM which was used clinically for cancer treatment in China. " 06/01/2022 - "It can also promote the scientific development of Chansu, and has great significance for enriching the application of TCM in the development of new anti-tumor drugs." 01/01/2019 - "The extracts of Chansu are used for various cancer treatments in China. " 03/14/2014 - "Although the anti-cancer properties of Chan Su have been investigated, no information exists regarding whether Chan Su has genotoxic effects in cancer cells. "
2.	Cardiac Arrhythmias (Arrythmia) 10/01/2011 - "Arrhythmia of mice were induced by Chansu and then electrocardiograms (ECGs) were recorded. " 10/01/2002 - "Chan Su is a Chinese medicine prepared from the skin gland of a Chinese toad and is used in treating arrhythmia and other heart diseases. " 10/01/2011 - "After pretreatment with lidocaine, the prolongation of P-R interval and broadening of QRS complex were inhibited, and the incidences of ventricular arrhythmia were reduced dramatically, while survival rate was improved; the isolated mouse hearts lethal dose of Chansu was increased significantly. " 10/01/2011 - "Compared with control group, after pretreatment with phenytoin sodium, broadening of QRS complex and HR were inhibited, and the incidence of ventricular arrhythmia was reduced dramatically, while survival rate was improved; the isolated mouse hearts lethal dose of Chansu was increased significantly. " 12/01/2017 - "These findings suggest that bufalin is a potent hERG K+ channel blocker and may provide a new way for understanding Chan Su-induced arrhythmia."
3.	Colorectal Neoplasms (Colorectal Cancer) 12/05/2023 - "Network pharmacology and metabolomics elucidate the underlying mechanisms of Venenum Bufonis in the treatment of colorectal cancer." 12/05/2023 - "The present study aims to evaluate the efficacy of Venenum Bufonis (VBF), a traditional Chinese medicine derived from the dried secretions of the Chinese toad, in treating colorectal cancer (CRC). " 01/01/2022 - "Meanwhile, the ChanSu active components (e.g., telocinobufagin, bufotalin, bufalin, cinobufotalin, and cinobufagin) exert great antitumor activity in many cancers, such as breast cancer, colorectal cancer, hepatocellular carcinoma and esophageal squamous cell carcinoma. "
4.	Poisoning 06/01/1999 - "The purpose of this study was to determine the efficacy of digoxin specific Fab fragments in treating Chan Su poisoning. " 06/01/1999 - "Digoxin specific Fab fragments are effective in the treatment of Chan Su poisoning in mice and may be effective for poisoning by other cardioactive steroids of the bufadienolide class." 10/10/2013 - "Causes of death were grouped into 6 categories, including 1 case of tetrodotoxin poisoning, 1 case of gallbladder poisoning, 3 cases of snake venom toxicity, 4 cases of melittin toxicity, 4 cases of cantharidin poisoning and 5 cases of venenum bufonis poisoning. "
5.	Infections 04/28/2020 - "Duttaphrynus melanostictus is the main source of traditional Chinese medicine "Chansu", which has anti-infection effect while without a clear mechanism. " 01/01/2014 - "The dried secretion from the auricular and skin glands of Chinese toad (Bufo bufo gargarizans) is named Chansu, which has been used in Traditional Chinese Medicine (TCM) for treating infection and inflammation for hundreds of years. " 01/01/2016 - "The traditional Chinese medicine Chan-Su is widely used for treatment of cancer and cardiovascular diseases, but also as a remedy for infections such as furunculosis, tonsillitis and acute pharyngitis. "

Related Drugs and Biologics

1.	bufalin
2.	cinobufagin
3.	Bufanolides
4.	Digoxin (Digitek)
5.	Steroids
6.	bufogenin
7.	Analgesics (Analgesic Drugs)
8.	Verapamil (Calan)
9.	Phenytoin (Dilantin)
10.	Lidocaine (Xylocaine)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Analgesia
3.	Therapeutics
4.	Local Anesthesia