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ShK neurotoxin

a potassium channel toxin from the Caribbean sea anemone Stichodactyla helianthus; amino acid sequence in first source

Also Known As:

ShK toxin

Networked: 4 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Cnidarian Venoms: 28
    - ShK neurotoxin: 4
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Cnidarian Venoms: 28
      - ShK neurotoxin: 4
  - Marine Toxins: 124
    - Cnidarian Venoms: 28
      - ShK neurotoxin: 4

Experts

1.	Gong, Guiyi: 1 article (12/2018)
2.	Lee, Simon Ming-Yuen: 1 article (12/2018)
3.	Liao, Qiwen: 1 article (12/2018)
4.	Rádis-Baptista, Gandhi: 1 article (12/2018)
5.	Siu, Shirley Weng In: 1 article (12/2018)
6.	Tse, Yu Chung: 1 article (12/2018)
7.	Wong, Clarence Tsun Ting: 1 article (12/2018)
8.	Yu, Huidong: 1 article (12/2018)
9.	Antunes, Agostinho: 1 article (01/2017)
10.	Campos, Alexandre: 1 article (01/2017)

Related Diseases

1.	Autoimmune Diseases (Autoimmune Disease) 03/15/2012 - "The ShK toxin from the sea anemone Stichodactyla helianthus is a potent blocker of Kv1.3. ShK-186, a synthetic analog of ShK, is being developed as a therapeutic for autoimmune diseases, and is scheduled to begin first-in-man phase-1 trials in 2011. "
2.	Cardiotoxicity 12/01/2018 - "The present results indicated that PcShK3 is a novel member of ShK toxin family, and has the intrinsic ability to induce neuro- and cardio-protective effects or cause cardiac toxicity, according to its effective concentration."
3.	Multiple Sclerosis 07/01/2005 - "The ShK toxin is a polypeptide that blocks the Kv1.3 potassium channel in T-lymphocytes and has been identified as a potential therapeutic for multiple sclerosis. "
4.	Bites and Stings (Sting) 01/01/2017 - "Among all the proteins identified in this work we highlight: Zinc metalloproteinase, which has a ShK toxin domain and therefore should be implicated in the sting toxicity of P. "

Related Drugs and Biologics

1.	Kv1.3 Potassium Channel
2.	Peptides (Polypeptides)
3.	Metalloproteases (Metalloproteinases)
4.	Zinc
5.	Proteins (Proteins, Gene)