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1H- (1,2,4)oxadiazolo(4,3- a)quinoxalin- 1- one

structure given in first source; inhibits guanylyl cyclase

Also Known As:

1H-ODQ; ODQ-1H

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: 2

Experts

1.	Ahanger, Azad Ahmed: 1 article (07/2011)
2.	Choudhury, Soumen: 1 article (07/2011)
3.	Kandasamy, Kathirvel: 1 article (07/2011)
4.	Mishra, Santosh Kumar: 1 article (07/2011)
5.	More, Amar Sunil: 1 article (07/2011)
6.	Parida, Subhashree: 1 article (07/2011)
7.	Prawez, Shahid: 1 article (07/2011)
8.	Singh, Thakur Uttam: 1 article (07/2011)
9.	Kanu, Alie: 1 article (11/2007)
10.	Leffler, Charles W: 1 article (11/2007)

Related Diseases

1.	Sepsis (Septicemia) 07/01/2011 - "Although basal cyclic guanosine monophosphate accumulation in the aorta was reduced in sepsis, pretreatment of the tissues with soluble guanylyl cyclase inhibitor 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (ODQ) partially restored the reactivity to NE. "
2.	Hypoxia (Hypoxemia) 11/01/2007 - "The guanylyl cyclase inhibitor, 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (ODQ), which blocked dilation to sodium nitroprusside, did not inhibit dilation to hypoxia. "

Related Drugs and Biologics

1.	Nitroprusside (Sodium Nitroprusside)
2.	Guanylate Cyclase (Guanylyl Cyclase)
3.	Guanosine Monophosphate (5' Guanylic Acid)
4.	Soluble Guanylyl Cyclase