|1.||Orr, Harry T: 17 articles (01/2015 - 01/2002)|
|2.||Zoghbi, Huda Y: 17 articles (01/2015 - 01/2002)|
|3.||de Chiara, Cesira: 9 articles (10/2014 - 05/2005)|
|4.||Pastore, Annalisa: 9 articles (10/2014 - 05/2005)|
|5.||Menon, Rajesh P: 7 articles (10/2014 - 05/2005)|
|6.||Botas, Juan: 6 articles (02/2008 - 05/2003)|
|7.||Hong, Sunghoi: 5 articles (05/2015 - 08/2003)|
|8.||Kang, Seongman: 5 articles (05/2015 - 08/2003)|
|9.||Vig, Parminder J S: 5 articles (10/2014 - 09/2005)|
|10.||Subramony, S H: 5 articles (09/2009 - 03/2000)|
|1.||Nervous System Diseases (Neurological Disorders)
01/01/2008 - "We conclude that antisense RNAs were effective in reducing or modifying ataxin-1 messages in transfected cells, and may be an effective genetic strategy for therapy of SCA1 and similar dominant-acting neurological disorders."
09/01/2012 - "Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurological disorder caused by the expansion of a polyglutamine tract in the mutant protein ataxin-1. "
|2.||Spinocerebellar Ataxias (Spinocerebellar Ataxia)
03/01/2014 - "In this study, we performed a systematic in vivo screen of all available Drosophila melanogaster homolog DNA repair genes, and we tested the effect of their overexpression on lifespan and developmental viability in Spinocerebellar Ataxia Type 1 (SCA1) Drosophila models expressing human mutant Ataxin-1 (Atxn1). "
06/27/2008 - "In this study, we report that UbcH6 interacts with and ubiquitinates ataxin-1, the spinocerebellar ataxia type 1 gene product. "
04/01/2014 - "We discuss the paradigmatic example of ataxin-1 (Atx1), the protein responsible for neurodegenerative spinocerebellar ataxia type 1 (SCA1). "
09/01/2013 - "A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1."
08/07/2013 - "We reported previously that mutant ataxin-1, a causative gene product of spinocerebellar ataxia type 1 (SCA1), prevents Bergmann glia proliferation in mutant ataxin-1 knockin mice and that suppressed Bergmann glia function leads to Purkinje cell degeneration. "
|3.||Neurodegenerative Diseases (Neurodegenerative Disease)
07/11/2014 - "Structural basis of the phosphorylation dependent complex formation of neurodegenerative disease protein Ataxin-1 and RBM17."
10/05/2007 - "The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2."
01/01/2014 - "The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by aggregation and misfolding of the ataxin-1 protein. "
11/04/2011 - "Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). "
11/01/2007 - "Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disorder caused by an expanded CAG trinucleotide repeats within the coding sequence of the ataxin-1 protein. "
09/01/2001 - "Overexpression of mutant ataxin-1 in Purkinje cells of transgenic mice results in a progressive ataxia and Purkinje cell pathology that are very similar to those seen in SCA1 patients. "
06/29/1999 - "These mice developed ataxia and Purkinje cell abnormalities similar to those seen in SCA1 transgenic mice carrying full-length mutant ataxin-1, but lacked NIs. "
07/15/1998 - "Mice lacking ataxin-1 are viable, fertile, and do not show any evidence of ataxia or neurodegeneration. "
10/30/1997 - "Normal ataxin-1 localizes to several nuclear structures approximately 0.5 microm across, whereas the expanded ataxin-1 localizes to a single approximately 2-microm structure, before the onset of ataxia. "
08/01/2014 - "The mutated ataxin-1 protein in spinocerebellar ataxia 1 (SCA1) targets Purkinje cells (PCs) of the cerebellum and causes progressive ataxia due to loss of PCs and neurons of the brainstem. "
|5.||Huntington Disease (Huntington's Disease)
02/01/2008 - "Spinocerebellar Ataxia type 1 (SCA1) and Huntington's disease (HD) are two polyglutamine disorders caused by expansion of a CAG repeat within the coding regions of the Ataxin-1 and Huntingtin proteins, respectively. "
05/19/2015 - "Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protein (APP) and Presenilin-1 (PSEN1) for Alzheimer's disease (AD), Huntingtin (HTT) for Huntington's disease, Parkin (PARK2) for Parkinson's disease, and Ataxin-1 (ATXN1) for spinocerebellar ataxia type 1. Our network reveals common signatures of protein degradation and misfolding and recapitulates known biology. "
05/01/2001 - "Thus the androgen receptor is one of a growing number of neurodegenerative disease-associated proteins, including huntingtin (Huntington's disease), ataxin-1 (spinocerebellar ataxia, type 1) and ataxin-3 (spinocerebellar ataxia, type 3), which show expansion of CAG triplet repeats. "
|2.||Proteins (Proteins, Gene)
|4.||Mutant Proteins (Protein, Mutant)
|6.||Proteasome Endopeptidase Complex (Proteasome)
|7.||Messenger RNA (mRNA)