multidrug resistance protein 3

a phospholipid flippase; member of the ABC protein superfamily; RefSeq NM_012623 (Abcb1b rat)

Also Known As:

ABCB4 protein, human; Abcb1 protein, rat; Abcb1a protein, mouse; Abcb1a protein, rat; Abcb1b protein, rat; MDR3 protein; Mdr1a protein, mouse; Mdr2 protein, rat; PGY3 protein; mdr-3 protein; mdr1a protein; multidrug resistance protein 1a, rat

Networked: 40 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dröge, Carola: 2 articles (12/2017 - 06/2015)
2.	Häussinger, Dieter: 2 articles (12/2017 - 06/2015)
3.	Keitel, Verena: 2 articles (12/2017 - 06/2015)
4.	Kluge, Stefanie: 2 articles (12/2017 - 06/2015)
5.	Kubitz, Ralf: 2 articles (12/2017 - 06/2015)
6.	Aleo, Michael D: 2 articles (01/2017 - 01/2017)
7.	Bonin, Paul D: 2 articles (01/2017 - 01/2017)
8.	He, Kan: 2 articles (01/2017 - 01/2017)
9.	Rodrigues, A David: 2 articles (01/2017 - 01/2017)
10.	Shah, Falgun: 2 articles (01/2017 - 01/2017)

Related Diseases

1.	Intrahepatic Cholestasis of Pregnancy 05/22/2023 - "Many studies have assessed the relationship between gene polymorphisms in multidrug resistance protein 3 (MDR3) and the risk of intrahepatic cholestasis of pregnancy (ICP); however, there are many conflicting narratives. " 11/07/2018 - "Progressive familial intrahepatic cholestasis type 3 is caused by a mutation in the ATP-binding cassette, subfamily B, member 4 (ABCB4) gene encoding multidrug resistance protein 3. A 32-year-old woman with a history of acute hepatitis at age 9 years was found to have jaundice during pregnancy in 2008, and was diagnosed as having intrahepatic cholestasis of pregnancy. "
2.	progressive familial intrahepatic 1 Cholestasis 05/01/2023 - "Gene therapy using recombinant adeno-associated virus (rAAV) vector carrying multidrug resistance protein 3 (MDR3) coding sequence (AAV8-MDR3) represents a potential curative treatment for progressive familial intrahepatic cholestasis type 3 (PFIC3), which presents in early childhood. " 12/01/2016 - "Progressive Familial Intrahepatic Cholestasis type 3 (PFIC3) is an autosomal-recessive liver disease due to mutations in the ABCB4 gene encoding for the MDR3 protein. " 03/01/2000 - "Furthermore, a group of progressive familial intrahepatic cholestasis patients with high serum gamma glutamyltranspeptidase have mutations in the gene (PGY3) coding for the MDR3 protein, a canalicular ATP-dependent phopshatidylcholine translocator. " 09/01/2015 - "Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. " 11/01/2009 - "Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3. We aimed to identify the proteins responsible for the surface expression of human ABCB4. "
3.	Cholestasis 01/01/2016 - "Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis." 12/14/2009 - "Multidrug resistance protein 3 R652G may reduce susceptibility to idiopathic infant cholestasis." 02/01/2013 - "Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia." 01/01/2016 - "While drug-induced cholestasis due to the inhibition of the bile salt export pump (BSEP) is well investigated, only limited information on the interaction of drugs with multidrug resistance protein 3 (MDR3) exists and its role in the pathogenesis of drug-induced cholestasis is poorly understood. " 04/01/2006 - "Multidrug Resistance Protein 3 (MRP3) transports bile salts and glucuronide conjugates in vitro and is postulated to protect the liver in cholestasis. "
4.	Chemical and Drug Induced Liver Injury 01/01/2017 - "Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals." 01/01/2017 - "Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals." 01/01/2022 - "Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epithelium. " 01/01/2022 - "Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition." 01/01/2007 - "Increasing evidence suggests that a genetically determined functional impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein 3 (MDR3, ABCB4) play a pathophysiological role in the development of drug-induced liver injury. "
5.	Intrahepatic Cholestasis 12/01/2017 - "The bile salt export pump (BSEP, ABCB11), multidrug resistance protein 3 (MDR3, ABCB4) and the ATPase familial intrahepatic cholestasis 1 (FIC1, ATP8B1) mediate bile formation. " 12/01/2015 - "Detection of mutations in genes encoding hepatobiliary transport proteins like familial intrahepatic cholestasis 1 (FIC1), bile salt export pump (BSEP), or multidrug resistance protein 3 (MDR3) is the basis to differentiate various forms of intrahepatic cholestasis. " 01/13/2022 - "One patient each with familial intrahepatic cholestasis 1 (FIC1) deficiency and bile salt export pump (BSEP) deficiency died after LDLT, and the four remaining patients, one each with deficiency of FIC1, BSEP, multidrug resistance protein 3 (MDR3), and tight junction protein 2 (TJP2), survived. " 06/01/2015 - "The three subtypes of PFIC are defined by the involved genes: PFIC-1, PFIC-2, and PFIC-3 are due to mutations of P-type ATPase ATP8B1 (familial intrahepatic cholestasis 1, FIC1), the ATP binding cassette transporter ABCB11 (bile salt export pump, BSEP), or ABCB4 (multidrug resistance protein 3, MDR3), respectively. "

Related Drugs and Biologics

1.	Member 11 Subfamily B ATP Binding Cassette Transporter
2.	Proteins (Proteins, Gene)
3.	Bile Acids and Salts (Bile Acids)
4.	Phosphatidylcholines (Phosphatidylcholine)
5.	Adenosine Triphosphate (ATP)
6.	ATP-Binding Cassette Transporters (ABC Transporters)
7.	Phospholipids (Phosphatides)
8.	Peptides (Polypeptides)
9.	Carrier Proteins (Binding Protein)
10.	Zonula Occludens-2 Protein

Related Therapies and Procedures

1.	Therapeutics