collapsin response mediator protein-2

an intracellular protein related to nematode neuronal protein UNC-33, from Xenopus laevis oocytes; expressed selectively in developing nervous system; RefSeq NM_001105717 for Dpysl2-Rat

Also Known As:

CRMP2 protein, human; CRMP2 protein, mouse; CRMP2 protein, rat; Collapsin response mediator protein 2, rat; DPYSL2 protein, human; DPYSL2 protein, rat; DRP-2 protein, human; DRP-2 protein, mouse; Dpysl2 protein, mouse; Musunc33 protein, mouse; TOAD-64 protein, mouse; dihydropyrimidinase related protein-2, human; dihydropyrimidinase related protein-2, mouse; dihydropyrimidinase-like 2 protein, human; dihydropyrimidinase-like 2 protein, mouse; dihydropyrimidinase-like 2 protein, rat; dihydropyrimidinase-related protein 2

Networked: 47 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakata, Kenji: 3 articles (02/2004 - 04/2003)
2.	Ujike, Hiroshi: 3 articles (02/2004 - 04/2003)
3.	Petratos, Steven: 2 articles (06/2018 - 06/2011)
4.	Steer, David L: 2 articles (06/2018 - 06/2011)
5.	Wu, Chih-Ching: 2 articles (04/2008 - 01/2008)
6.	Yu, Jau-Song: 2 articles (04/2008 - 01/2008)
7.	Imamura, Takaki: 2 articles (10/2003 - 04/2003)
8.	Kuroda, Shigetoshi: 2 articles (10/2003 - 04/2003)
9.	Sakai, Ayumu: 2 articles (10/2003 - 04/2003)
10.	Takaki, Manabu: 2 articles (10/2003 - 04/2003)

Related Diseases

1.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2020 - "Our recent study investigated the role of collapsin response mediator protein-2 (CRMP2) on dendritic spine morphology and memory function after traumatic brain injury (TBI). " 04/05/2015 - "Propofol ameliorates calpain-induced collapsin response mediator protein-2 proteolysis in traumatic brain injury in rats." 04/05/2015 - "Collapsin response mediator protein-2 (CRMP2), a multifunctional cytosolic protein highly expressed in the brain, is degraded by calpain following traumatic brain injury (TBI), possibly inhibiting posttraumatic neurite regeneration. " 06/01/2013 - "Experimental activation of calpains via traumatic brain injury resulted in cleavage of α-spectrin, collapsin response mediator protein-2, and voltage-gated sodium channel, critical proteins for the maintenance of neuronal structure and function. "
2.	Low Tension Glaucoma 08/01/2022 - "Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models."
3.	Schizophrenia (Dementia Praecox) 07/05/2005 - "A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase-related protein 2 (DRP-2) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571-576]. " 07/05/2005 - "Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia." 02/01/2004 - "[The human dihydropyrimidinase-related protein 2 (DRP-2) gene on chromosome 8p21 is associated with paranoid-type schizophrenia]." 10/09/2003 - "Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. " 04/01/2003 - "The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia."
4.	Brain Ischemia (Cerebral Ischemia) 10/17/2005 - "Studies determined for the first time whether collapsin response mediator protein-2 expression is altered in brain ischemia. " 05/04/2023 - "Dihydropyrimidinase-Related Protein 2 Is a New Partner in the Binding between 4E-BP2 and eIF4E Related to Neuronal Death after Cerebral Ischemia." 06/01/2007 - "Upregulation of dihydropyrimidinase-related protein 2, spectrin alpha II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats--a proteomics approach." 11/01/2010 - "Among the identified protein spots, we validated the results of 10 proteins by Western blot and determined the cellular localization in brain parenchyma for 3 of the identified proteins: dihydropyrimidinase-related protein 2, vesicle-fusing ATPase, and Rho dissociation inhibitor 1. These results contribute to understanding the processes that follow cerebral ischemia; moreover, some of the identified proteins may be therapeutic targets or biologic markers for determining the diagnosis and prognosis of stroke."
5.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2022 - "This study verified the effectiveness of riluzole and speculated that a riluzole-afforded protection mechanism may be associated with the glycogen synthase kinase-3 beta (GSK-3β)/collapsin response mediator protein-2 (CRMP-2) pathway in rats after spinal cord injury. " 11/01/2018 - "Increased Levels of Circulating Glial Fibrillary Acidic Protein and Collapsin Response Mediator Protein-2 Autoantibodies in the Acute Stage of Spinal Cord Injury Predict the Subsequent Development of Neuropathic Pain."

Related Drugs and Biologics

1.	Propofol (Diprivan)
2.	Calpain
3.	Proteins (Proteins, Gene)
4.	Myosin Light Chains (Myosin Essential Light Chain)
5.	Glycogen Synthase (Synthase I)
6.	Single-Domain Antibodies
7.	Cyclin-Dependent Kinase 5
8.	Semaphorin-3A
9.	Riluzole
10.	Vimentin