cytochrome P-450 CYP4B1 (CYP4B1)

a cytochrome P-450 enzyme with broad substrate specificity; oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; mouse, human, rabbit & rat CYP4B1 are highly homologous; belongs to the CYP4B subfamily; N-terminal amino acid sequence given in first source

Also Known As:

Networked: 49 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dunn, Michael W: 4 articles (11/2007 - 02/2004)
2.	Rettie, Allan E: 3 articles (01/2019 - 01/2006)
3.	Mezentsev, Alexandre: 3 articles (11/2007 - 04/2004)
4.	Ashkar, Silvia: 3 articles (10/2005 - 02/2004)
5.	Laniado-Schwartzman, Michal: 3 articles (10/2005 - 02/2004)
6.	Mastyugin, Vladimir: 3 articles (10/2005 - 02/2004)
7.	Funae, Y: 3 articles (06/2001 - 11/2000)
8.	Hiroi, T: 3 articles (06/2001 - 11/2000)
9.	Imaoka, S: 3 articles (06/2001 - 11/2000)
10.	Jang, Su Jin: 2 articles (10/2013 - 09/2010)

Related Diseases

1.	Carcinogenesis 05/26/2001 - "In this study, regulation of CYP4B1 was investigated to elucidate sex difference in bladder carcinogenesis. " 05/26/2001 - "Furthermore, the present findings suggest that the sex difference observed in bladder carcinogenesis was due to sex-different expression of CYP4B1 in bladder tissue." 08/01/1995 - "In extrahepatic tissue, CYP4B1 may contribute to chemical carcinogenesis." 01/01/2017 - "This study investigates a potential role for CYP4B1 in modulating adrenocortical tumorigenesis and/or conferring chemoresistance to adrenocortical carcinomas. " 01/01/2017 - "CYP4B1 is silenced in both benign and malignant adrenocortical tumors and may contribute to tumorigenesis and chemoresistance. "
2.	Carcinoma (Carcinomatosis) 09/15/1997 - "To assess the contribution of CYP4B1 to bladder carcinoma, further investigation was done with the umu test and an immunochemical study. " 04/01/2019 - "The objective of this study was to examine the expression level of cytochrome P450 4B1 (CYP4B1) protein and its clinical significance in specimens from patients with urothelial carcinomas (UC) including upper tract urothelial carcinoma (UTUC, n = 340) and urinary bladder urothelial carcinoma (UBUC, n = 295). "
3.	Neoplasms (Cancer) 06/01/2020 - "The involvement of CYP4B1 in cancer was considered via activation of procarcinogens and neovascularization. " 06/01/2020 - "However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive. " 02/15/1994 - "Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors." 01/20/2023 - "This review will summarize the current status of CYP4B1 research with a spotlight on its roles in the metabolism of endogenous and exogenous compounds, structural properties, and cancer association, as well as its potential application in suicide gene approaches for targeted cancer therapy." 01/01/2021 - "In this study, using data from The Cancer Genome Atlas (TCGA) project and the Gene Expression Omnibus (GEO) database, a secondary analysis was performed to explore the expression profile of CYP4B1, as well as its prognostic value in patients with lung adenocarcinoma (LUAD). "
4.	Neoplasm Metastasis (Metastasis) 01/01/2021 - "Bioinformatic analysis shows five hub LUAD metastasis driver genes (RHOV, ZIC5, CYP4B1, GPR18 and TCP10L2), among which RHOV is the most significant gene associated with LUAD metastasis. " 04/01/2019 - "Correlations between CYP4B1 H-score and important clinicopathological factors, as well as the significance of CYP4B1 expression level for disease-specific and metastasis-free survivals were evaluated. " 06/26/2022 - "Additionally, the NSCLC metastasis-specific regulation network was constructed, and six key PDEEs were defined (ANXA8L1, CASTOR2, CYP4B1, GTF2H2C, PSMF1 and TNS4); (4) Conclusions: This study focused on the exploration of the prognostic value of eRNAs in the metastasis of NSCLC. " 04/01/2019 - "Low CYP4B1 protein level independently predicted inferior disease-specific (p = 0.009; p < 0.001) and metastasis-free (p = 0.035; p < 0.001) survivals in UTUC and UBUC patients. " 04/01/2019 - "Downregulation of CYP4B1 protein was correlated to advanced primary tumor (p < 0.001), nodal metastasis (p < 0.001), high histological grade (p = 0.001), vascular invasion (p < 0.001), perineural invasion (p = 0.017) and mitotic rate (p = 0.036) in UTUCs and/or UBUCs. "
5.	Lung Neoplasms (Lung Cancer) 11/11/2023 - "Missense variants in CYP4B1 associated with increased risk of lung cancer among Chinese Han population." 01/01/2011 - "In contrast, there was no association between the known CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1 polymorphisms and lung cancer. " 01/01/2011 - "Association between cancer risk and drug-metabolizing enzyme gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) polymorphisms in cases of lung cancer in Japan." 02/15/1994 - "We analyzed the expression of CYP2B7, CYP4B1, and NADPH-cytochrome P450 oxidoreductase (OR) mRNAs in normal lung controls, normal lung from lung cancer patients, and lung tumors using the sensitive technique of RNase protection. " 01/01/2011 - "The purpose of this study was to investigate the relationship between lung cancer cases in Japan and variant alleles of cytochrome P450 (CYP) 2A6 (CYP2A6*4), CYP2A13 (CYP2A13*1-*10), CYP4B1 (CYP4B1*1-*7), sulfotransferase 1A1 (SULT1A1*2), glutathione S-transferase M1 (GSTM1 null), and glutathione S-transferase T1 (GSTT1 null). "

Related Drugs and Biologics

1.	Cytochrome P-450 Enzyme System (Cytochrome P450)
2.	Proteins (Proteins, Gene)
3.	Protein Isoforms (Isoforms)
4.	Cytochrome P-450 CYP2E1 (CYP2E1)
5.	Complementary DNA (cDNA)
6.	Transcription Factors (Transcription Factor)
7.	Cytochrome P-450 CYP2C8
8.	A-Form DNA (A-DNA)
9.	Sulfotransferases
10.	Recombinant Fusion Proteins

Related Therapies and Procedures

1.	Therapeutics
2.	Sutures (Suture)
3.	Contact Lenses
4.	Aftercare (After-Treatment)