leiomyoma-derived growth factor

may participate in the pathophysiology of uterine leiomyomas; partial NH2-terminal amino acid (aa) sequence (1-20 aa) was identical to 113-132 aa of the human cysteine-rich protein; amino acid sequence has been determined

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Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Leukemia 12/01/1984 - "LDGF was able to stimulate growth of the human leukemia T-cells MOLT4f, and the LDGF from MOLT4f cells stimulated the mouse cells. " 03/01/1986 - "An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. " 12/01/1984 - "This factor was designated leukemia-derived growth factor (LDGF). " 03/16/1988 - "By using an assay system in which small numbers of murine T lymphoma cells are stimulated to grow in serum-free medium, we have continued and expanded our previous studies of an autocrine growth factor that we call leukemia-derived growth factor (LDGF). "
2.	Lymphoma (Lymphomas) 03/16/1988 - "However, growth-stimulating activity for the murine lymphoma cells is provided by a partially purified human LDGF." 03/16/1988 - "We show that a T lymphoma cell line of immature phenotype, adapted to growth in serum-free medium, produces and responds to LDGF. " 03/16/1988 - "By using an assay system in which small numbers of murine T lymphoma cells are stimulated to grow in serum-free medium, we have continued and expanded our previous studies of an autocrine growth factor that we call leukemia-derived growth factor (LDGF). "
3.	Leiomyoma (Uterine Fibroids) 08/01/1995 - "These data suggest that LDGF may participate in the pathophysiology of uterine leiomyomas." 08/01/1995 - "The expression of the LDGF mRNA was three to sixfold higher in leiomyomas compared with adjacent myometrium of women harboring leiomyomas by in situ hybridization analysis. " 08/01/1995 - "An oligonucleotide probe constructed by the cDNA of the hcrp gene that encodes this aa sequence depicted the expression of 1.9-kb LDGF mRNA in leiomyomas and myometrium. "

Related Drugs and Biologics

1.	Intercellular Signaling Peptides and Proteins (Growth Factors)
2.	Complementary DNA (cDNA)
3.	Oligonucleotide Probes
4.	Messenger RNA (mRNA)