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NIK 250
Also Known As:
NIK-250; NIK250; bis(4-pyridylmethyl)-4-(2-(3-methyl-5,6-dihydro-1,4-dithiinyl))-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; bis(pyridin-4-ylmethyl)-2,6-dimethyl-4-(3-methyl-5,6-dihydro-1,4-dithiin-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Dihydropyridines: 214
NIK 250: 2
Inorganic Chemicals: 9
Sulfur Compounds: 278
NIK 250: 2
Organic Chemicals: 133
Sulfur Compounds: 278
NIK 250: 2
Related Diseases
1.
Glioma (Gliomas)
08/01/1995 - "
NIK250 or verapamil might exert inhibitory effects upon MRP function, resulting in a reversal of MRP-mediated spontaneous multidrug resistance in cultured human glioma cells.
"
08/01/1995 - "
In this study, we investigated whether chemosensitising agents of P-glycoprotein-mediated multidrug resistance such as verapamil, a biscoclaurine alkaloid (cepharanthine), and a dihydropyridine analogue (NIK250) could also reverse multidrug resistance in human glioma cells.
"
2.
Prostatic Neoplasms (Prostate Cancer)
09/01/1995 - "
NIK250 might be useful in reversing MDR, which often develops during chemotherapy of advanced or hormone-resistant prostatic cancer.
"
Related Drugs and Biologics
1.
Member 1 Subfamily B ATP Binding Cassette Transporter
2.
Verapamil (Calan)
3.
Alkaloids
4.
1,4-dihydropyridine (dihydropyridine)
5.
cepharanthine
6.
Hormones (Hormone)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)