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GI 168

a matrix metalloproteinase inhibitor

Also Known As:

GI-168; GI168; N4-hydroxy-2-(2-methylpropyl)-N1-(2-(2-(morpholinyl)ethyl))butanediamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - GI 168: 1

Related Diseases

1.	Experimental Arthritis 08/01/1995 - "We have identified butanediamide, N4-hydroxy-2-(2-methylpropyl)-N1-[2-[[2-(morpholinyl)ethyl]-,[S- (R,S)] (GI168) as a potent MMP inhibitor with sufficient solubility and stability to permit evaluation in an experimental model of chronic destructive arthritis (adjuvant-induced arthritis) in rats. "
2.	Arthritis (Polyarthritis) 08/01/1995 - "This unique profile of antiarthritic activity indicates that GI168 is osteo- and chondro-protective, and it supports a direct role for MMP in cartilage and bone damage and pannus formation in adjuvant-induced arthritis." 08/01/1995 - "We have identified butanediamide, N4-hydroxy-2-(2-methylpropyl)-N1-[2-[[2-(morpholinyl)ethyl]-,[S- (R,S)] (GI168) as a potent MMP inhibitor with sufficient solubility and stability to permit evaluation in an experimental model of chronic destructive arthritis (adjuvant-induced arthritis) in rats. "

Related Drugs and Biologics

1.	Matrix Metalloproteinase Inhibitors
2.	Matrix Metalloproteinases (MMPs)