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Injectable No. 1
a Chinese compound containing 250mg 17alpha-hydroxyprogesterone caproate & 5mg estradiol valerate
Also Known As:
Chinese HRP3; Chinese Injectable No. 1
Networked:
3
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Pregnanes: 9
Pregnenes: 1
Pregnenediones
Progesterone: 12723
Hydroxyprogesterones
Injectable No. 1: 3
Estranes
Estrenes
Estradiol: 14115
Injectable No. 1: 3
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Gonadal Hormones: 716
Gonadal Steroid Hormones: 7657
Estradiol Congeners: 358
Estradiol: 14115
Injectable No. 1: 3
Progesterone Congeners: 320
Progesterone: 12723
Hydroxyprogesterones
Injectable No. 1: 3
Related Diseases
1.
Hemorrhage
03/01/1995 - "
The study was restarted with a revised injection schedule for Injectable No. 1: two injections separated by 9 +/- 1 days during the first month and subsequent injections given 10-12 days after the onset of bleeding, or if no bleeding occurred, 28 days after previous injection.
"
03/01/1995 - "
Acceptable bleeding patterns (i.e., bleeding patterns similar to untreated patterns) predominated, on the most part, in all four periods (63.7-82.2% for Mesigyna users, 41.4-67.8% for Cyclofem users, and 60.6-75% for Injectable No.1 users).
"
03/01/1995 - "
63.7%, 41.4% and 60.6% of subjects using Mesigyna, Cyclofem and Injectable No. 1, respectively, had bleeding patterns similar to their untreated patterns in the first 90-day period.
"
03/01/1995 - "
In total, 902, 903 and 913 diaries were analyzed to compare bleeding patterns induced by Mesigyna, Cyclofem and Injectable No. 1. The first withdrawal bleeding usually occurs 14-20 days after the first injection for all three of these preparations.
"
03/01/1995 - "
Relative to users of Mesigyna or Cyclofem, Injectable No. 1 users had 2-3 more bleeding/spotting days, and a shorter length of bleeding/spotting-free intervals in each period.
"
2.
Hyperplasia
04/01/1994 - "
A longitudinal study indicated that there is no accumulation of norethisterone after 12 months of treatment with NET-EN 50 mg and estradiol valerate 5 mg. About 1 million women in Latin America and China have used the 1st generation once-a-month combined injectable contraceptives Deladroxate and Chinese Injectable No. 1. Animal toxicity studies of Deladroxate found pituitary hyperplasia in rats, breast tumors in beagles, and accumulation of estradiol enanthate in the body.
"
3.
Breast Neoplasms (Breast Cancer)
04/01/1994 - "
A longitudinal study indicated that there is no accumulation of norethisterone after 12 months of treatment with NET-EN 50 mg and estradiol valerate 5 mg. About 1 million women in Latin America and China have used the 1st generation once-a-month combined injectable contraceptives Deladroxate and Chinese Injectable No. 1. Animal toxicity studies of Deladroxate found pituitary hyperplasia in rats, breast tumors in beagles, and accumulation of estradiol enanthate in the body.
"
4.
Metrorrhagia (Spotting)
03/01/1995 - "
Relative to users of Mesigyna or Cyclofem, Injectable No. 1 users had 2-3 more bleeding/spotting days, and a shorter length of bleeding/spotting-free intervals in each period.
"
03/01/1995 - "
Thereafter, 50% of Mesigyna users had precisely 3 bleeding/spotting episodes every 90 days, 50% of Cyclofem users had 2-3 and 50% of Injectable No. 1 users had 3-4 episodes every 90 days.
"
03/01/1995 - "
The number of bleeding/spotting days over four periods showed little difference between the two group, but there were more spotting days and there was greater individual variability among Cyclofem users.(ABSTRACT TRUNCATED AT 250 WORDS) Between October 1988 and July 1990, a randomized multicentered phase III clinical trial was conducted in three provinces of China to compare three monthly injectable contraceptives (Mesigyna [50 mg norethisterone enanthate + 5 mg estradiol valerate], Cyclofem [25 mg medroxyprogesterone acetate + 5 mg estradiol cypionate], and Injectable No.1 [250 mg 17-hydroxyprogesterone caproate + 5 mg estradiol valerate]).
"
5.
Confusion (Bewilderment)
04/01/1994 - "
For injectable No. 1, its disadvantage of being administered on an erratic schedule will cause significant confusion in family planning practice.
"
Related Drugs and Biologics
1.
Estradiol (Delestrogen)
2.
Contraceptive Agents (Contraceptives)
3.
Norethindrone (Norethisterone)
4.
deladroxate
5.
estradiol enanthate
6.
norethindrone drug combination estradiol
7.
CycloProvera
8.
17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)
9.
Medroxyprogesterone Acetate (Depo-Provera)
10.
hexanoic acid (hexanoate)
Related Therapies and Procedures
1.
Injections