HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
glutamyl- isoleucyl- leucyl- aspartyl- valine
fragment of fibronectin that binds to alpha4beta1 integrin; do not confuse with cleavage signal-1 protein, also called CS-1 protein
Also Known As:
CS-1 peptide, integrin-binding; EILDV peptide; Glu-Ile-Leu-Asp-Val
Networked:
5
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Carrier Proteins: 12999
glutamyl-isoleucyl-leucyl-aspartyl-valine: 5
Peptides: 82426
Oligopeptides: 519
glutamyl-isoleucyl-leucyl-aspartyl-valine: 5
Experts
1.
Chaudhari, Kiran
: 1 article (01/2011)
2.
Gude, Rajiv
: 1 article (01/2011)
3.
Manjappa, A S
: 1 article (01/2011)
4.
Murthy, R S R
: 1 article (01/2011)
5.
Rajyaguru, Tushar
: 1 article (01/2011)
6.
Ukawala, Mukesh
: 1 article (01/2011)
Related Diseases
1.
Neoplasms (Cancer)
12/01/1995 - "
AcDRLDS also inhibited tumor cell adhesion to CS1 as well as the RGDS sequence within the fibronectin molecule in a concentration-dependent manner, although the inhibitory effect was less than that of the CS1 (EILDV) peptide.
"
08/01/1997 - "
The aim of this study was to increase the antimetastatic potency of the fibronectin-related peptide, Glu-Ile-Leu-Asp-Val (EILDV), and to determine the minimal core sequence of EILDV required to inhibit tumor metastasis in vivo.
"
12/01/1996 - "
A mixture composed of PEG hybrids of Glu-Ile-Leu-Asp-Val, Arg-Glu-Asp-Val and Tyr-Ile-Gly-Ser-Arg dramatically inhibited tumor metastasis.
"
01/01/2011 - "
In the present study, poly(ethylene glycol)-b-poly(ε-caprolactone) micelles loaded with etoposide (ETO) were formulated and further conjugated with pentapeptide Glu-Ile-Leu-Asp-Val (EILDV) to target α4β1 integrin receptor overexpressed on metastatic tumor cell.
"
2.
Neoplasm Metastasis (Metastasis)
08/01/1997 - "
The aim of this study was to increase the antimetastatic potency of the fibronectin-related peptide, Glu-Ile-Leu-Asp-Val (EILDV), and to determine the minimal core sequence of EILDV required to inhibit tumor metastasis in vivo.
"
12/01/1996 - "
A mixture composed of PEG hybrids of Glu-Ile-Leu-Asp-Val, Arg-Glu-Asp-Val and Tyr-Ile-Gly-Ser-Arg dramatically inhibited tumor metastasis.
"
12/01/1996 - "
In the in vivo assay, we found that the synthetic peptides containing Glu-Ile-Leu-Asp-Val and Arg-Glu-Asp-Val sequences exhibited an inhibitory effect on the experimental metastasis of B16-BL6 melanoma.
"
3.
Melanoma (Melanoma, Malignant)
12/01/1996 - "
In the in vivo assay, we found that the synthetic peptides containing Glu-Ile-Leu-Asp-Val and Arg-Glu-Asp-Val sequences exhibited an inhibitory effect on the experimental metastasis of B16-BL6 melanoma.
"
01/01/1993 - "
We have extended the observation to another cell-adhesive sequence, Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (referred to as "CS1" sequence), to demonstrate that: i) the tSPA grafted with the sequence mediated adhesion of human lymphoma and rhabdomyosarcoma cells, mouse melanoma cells, but not of hamster fibroblasts; ii) antibodies against integrin alpha 4 and beta 1 subunits specifically inhibited cell adhesion mediated by the CS1-grafted tSPA; iii) a heterodivalent tSPA grafted with both RGDS and CS1 sequences at different sites was more potent in promoting cell adhesion than the monovalent tSPAs grafted with either sequence alone.
"
4.
Rhabdomyosarcoma
01/01/1993 - "
We have extended the observation to another cell-adhesive sequence, Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (referred to as "CS1" sequence), to demonstrate that: i) the tSPA grafted with the sequence mediated adhesion of human lymphoma and rhabdomyosarcoma cells, mouse melanoma cells, but not of hamster fibroblasts; ii) antibodies against integrin alpha 4 and beta 1 subunits specifically inhibited cell adhesion mediated by the CS1-grafted tSPA; iii) a heterodivalent tSPA grafted with both RGDS and CS1 sequences at different sites was more potent in promoting cell adhesion than the monovalent tSPAs grafted with either sequence alone.
"
5.
Lymphoma (Lymphomas)
01/01/1993 - "
We have extended the observation to another cell-adhesive sequence, Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (referred to as "CS1" sequence), to demonstrate that: i) the tSPA grafted with the sequence mediated adhesion of human lymphoma and rhabdomyosarcoma cells, mouse melanoma cells, but not of hamster fibroblasts; ii) antibodies against integrin alpha 4 and beta 1 subunits specifically inhibited cell adhesion mediated by the CS1-grafted tSPA; iii) a heterodivalent tSPA grafted with both RGDS and CS1 sequences at different sites was more potent in promoting cell adhesion than the monovalent tSPAs grafted with either sequence alone.
"
Related Drugs and Biologics
1.
Integrins
2.
Peptides (Polypeptides)
3.
Fibronectins (Fibronectin)
4.
Ethylene Glycol (Monoethylene Glycol)
5.
Micelles
6.
Etoposide (VP 16)
7.
caprolactone
8.
Antibodies
9.
prolyl-serine (Pro-Ser)
10.
tyrosyl-isoleucyl-glycyl-seryl-arginine