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Description: a topoisomerase II inhibitor; structure given in first source; RN given refers to (S)-isomer (WIN 58161)
Also Known As:| 1. | Neoplasms (Cancer)
06/29/1995
- "When studied in tumor-bearing mice, WIN 58161 exhibited a significant antitumor effect against each of five tumors tested, whereas neither toxicity nor antitumor activity was observed with WIN 58161-2. We conclude from these studies that WIN 58161 represents the prototype of a novel chemical class of topoisomerase II inhibitor with potential clinical utility in treating cancer."
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| 2. | Leukemia
06/29/1995
- "At drug concentrations that are cytotoxic to P388 murine leukemia cells, WIN 58161 promoted intracellular DNA single-strand breaks (SSBs) that exhibited the hallmarks of being mediated by topoisomerase"
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| 2 Diseases and 1 more articles analyzed in the Research Interface, order at left... | |
| 1. | Type II DNA Topoisomerases (Topoisomerase II)
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| 2. | DNA (Deoxyribonucleic Acid)
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| 2 Drugs and Important Bio-Agents and 1 more articles analyzed in the Research Interface, order at left... | |
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