noribogaine

01/01/2020 - "Ample preclinical evidence demonstrated the efficacy of ibogaine, and its main metabolite, noribogaine, in substance-use-disorder rodent models. "
01/01/2016 - "This study investigated the effects of noribogaine, the principal metabolite of the drug ibogaine, on substance-related disorders. "
01/01/2023 - "Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature."
12/01/2015 - "Because elevated levels of dynorphins are commonly observed and correlated with anxiety, dysphoric effects, and decreased dopaminergic tone, a therapeutically relevant functional inhibition bias to endogenously released dynorphins by noribogaine might be worthy of consideration for treating anxiety and substance related disorders."
09/01/2006 - "In the present paper, we report for the first time the tissue distribution of ibogaine and noribogaine, the main metabolite of ibogaine, in a 48-year-old Caucasian male, with a history of drug abuse, found dead at his home after a poisoning involving the ingestion of root bark from the shrub Tabernanthe iboga. "

01/01/2021 - "Benchmark dose analysis of the predicted dose response curves adequately predicted the onset of in vivo cardiotoxicity detected by QTc prolongation upon oral exposure to ibogaine and noribogaine. "
01/01/2021 - "The aim of the present study was to investigate the applicability of an in vitro-in silico approach to predict human cardiotoxicity of the herbal alkaloid ibogaine and its metabolite noribogaine, which are promising anti-addiction drugs. "

06/01/2015 - "Smoking cessation has major benefits for both individuals and society, therefore the aim of this study was to evaluate the potential of noribogaine for use as a treatment for nicotine dependence. "

05/01/2001 - "Ibogaine caused dose-related increases in tremors, whereas noribogaine did not. "
03/25/1996 - "All of these effects were similar to effects previously observed with ibogaine (40 mg/kg); however, noribogaine did not induce any ibogaine-like tremors. "

09/01/2016 - "Noribogaine is an iboga alkaloid being studied for the treatment of opioid dependence. "
01/01/2022 - "Therefore, in this narrative review, we analyze current literature regarding use of the alternative medications ketamine, noribogaine, and cannabinoids in treating patients suffering from opioid use disorder. "
01/01/2022 - "Historical Pathways for Opioid Addiction, Withdrawal with Traditional and Alternative Treatment Options with Ketamine, Cannabinoids, and Noribogaine: A Narrative Review."