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trachyspic acid

isolated from Talaromyces trachyspermus; inhibits heparanase; structure given in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - trachyspic acid: 2
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - trachyspic acid: 2

Experts

1.	Esumi, Tomoyuki: 1 article (03/2003)
2.	Hatakeyama, Susumi: 1 article (03/2003)
3.	Hirai, Kanako: 1 article (03/2003)
4.	Iwabuchi, Yoshiharu: 1 article (03/2003)
5.	Ooi, Hidenori: 1 article (03/2003)

Related Diseases

1.

Neoplasms (Cancer)

05/01/1995 - "Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and biological activity."
03/20/2003 - "[reaction: see text] The first total synthesis of (+/-)-trachyspic acid, a tumor cell heparanase inhibitor, was accomplished based on Cr(II)/Ni(II)-mediated reaction of the aldehyde containing the citric acid moiety and the long-chain triflate, and the relative configuration of this natural product was determined."

Related Drugs and Biologics

1.	heparanase
2.	Citric Acid (Citrate)
3.	Aldehydes