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LY 290181

blocks interleukin-1-stimulated metalloprotease activity; structure given in first source

Also Known As:

2-amino-4-(3-pyridyl)-4H-naphtho-(1,2-b)pyran-3-carbonitrile; LY-290181; LY290181

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        LY 290181: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - LY 290181: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - LY 290181: 3

Experts

1.	Andronache, Ion: 1 article (02/2019)
2.	Biersack, Bernhard: 1 article (02/2019)
3.	Gold, Madeleine: 1 article (02/2019)
4.	Mueller, Thomas: 1 article (02/2019)
5.	Rothemund, Matthias: 1 article (02/2019)
6.	Schmitt, Florian: 1 article (02/2019)
7.	Schobert, Rainer: 1 article (02/2019)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2023 - "Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers. " 02/01/2019 - "New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents." 07/01/2023 - "In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. " 07/01/2023 - "These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. "
2.	Breast Neoplasms (Breast Cancer) 07/01/2023 - "Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1." 07/01/2023 - "In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. "
3.	Acute Erythroblastic Leukemia (Erythroleukemia) 09/01/1997 - "LY290181 is a potent inhibitor of cell proliferation, producing 50% inhibition of vascular smooth muscle, endothelial, Chinese hamster ovary, HeLa, and human erythroleukemia cells at concentrations of 8-40 nM. Cell cycle analysis showed that LY290181 caused accumulation of smooth muscle cells at the G2/M phase and induced mitotic arrest in Chinese hamster ovary cells and HeLa cells. "

Related Drugs and Biologics

1.	Twist-Related Protein 1