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4-S-cysteaminylcatechol

an activated form of 4-S-cysteaminylphenol; structure given in first source

Also Known As:

4-S-CAC

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Mercaptoethylamines
      - Cysteamine: 1042
        4-S-cysteaminylcatechol: 2
- Sulfur Compounds: 278
  - Sulfhydryl Compounds: 4168
    - Mercaptoethylamines
      - Cysteamine: 1042
        4-S-cysteaminylcatechol: 2

Related Diseases

1.	Melanoma (Melanoma, Malignant) 06/15/1995 - "4-S-CAC was the most cytotoxic to three lines of melanoma cells in vitro, followed by 2-S-CAH and 3-S-CAC. " 06/15/1995 - "4-S-CAC was found to be a better substrate for melanoma tyrosinase than was L-3,4-dihydroxyphenylalanine, the natural catecholic substrate. " 05/15/1997 - "In vitro experiments showed that (1) the cytotoxicity of 4-S-CAC was mostly prevented by catalase and superoxide dismutase, (2) BQ was highly cytotoxic to B16 melanoma cells (IC50 being 3.9 microM as compared with 507 microM for 4-S-CAP), (3) BQ was metabolized rapidly to a GSH adduct in melanoma cells, and (4) the same GSH adduct was also formed upon incubation of melanoma cells with 4-S-CAP, the reaction being tyrosinase dependent. "
2.	Experimental Melanoma 05/15/1997 - "In vitro experiments showed that (1) the cytotoxicity of 4-S-CAC was mostly prevented by catalase and superoxide dismutase, (2) BQ was highly cytotoxic to B16 melanoma cells (IC50 being 3.9 microM as compared with 507 microM for 4-S-CAP), (3) BQ was metabolized rapidly to a GSH adduct in melanoma cells, and (4) the same GSH adduct was also formed upon incubation of melanoma cells with 4-S-CAP, the reaction being tyrosinase dependent. "

Related Drugs and Biologics

1.	Monophenol Monooxygenase (Tyrosinase)
2.	Levodopa (L Dopa)
3.	Catalase
4.	superoxide dismutase 2