magnolin

01/01/2019 - "In this study, we screened the therapeutic potential of magnolin using 15 human cancer cell lines and combined magnolin sensitivity with the CCLE mutaome analysis for relevant mutation information. "
04/23/2023 - "In conclusion, magnolin showed robust anticancer activity against many cancer cell lines by altering several cancer signaling pathways in various non- and pre-clinical experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research."
11/14/2022 - "Additionally, magnolin was observed to limit PANC-1 tumor cell migration in the tumor cell wound healing assay, indicating a substantial anti-migratory effect against the PANC-1 cell line. "
11/14/2022 - "Furthermore, magnolin was able to induce a concentration-dependent suppression of the formation of PANC-1 colonies, where the treatment of the tumor cells with 25 nM, 50 nM, and 100 nM concentrations of the compound resulted in a 36%, 57, and 78% reduction, respectively, in the PANC-1 colony formation. "
01/01/2018 - "Magnolin is a multi-bioactive natural compound that possesses underlying anti-cancer properties. "

01/01/2020 - "The aim of this study was to evaluate the effects of Magnolin (MGL) on inhibition of human breast cancer cells, and explore the underlying molecular mechanisms. "
01/01/2020 - "Magnolin Inhibits Proliferation and Invasion of Breast Cancer MDA-MB-231 Cells by Targeting the ERK1/2 Signaling Pathway."
02/01/2014 - "Aschatin, fargesin, lirioresinol B dimethyl ether, and magnolin at noncytotoxic concentrations suppressed mRNA expression and secretion of osteolytic factor PTHrP in MDA-MB-231 metastatic human breast cancer cells. "
02/01/2014 - "Aschatin, fargesin, lirioresinol B dimethyl ether, and magnolin blocked initiation and progression of the "vicious cycle" between breast cancer metastases and bone microenvironment by inhibiting PTHrP production in breast cancer cells and osteoclastic bone resorption. "

03/01/2017 - "This study used cell culture and the BALB/c nu/nu mouse xenograft model to investigate whether or not magnolin can inhibit the growth of PC3 and Du145 prostate cancer cells. "
03/01/2017 - "To elucidate the possible mechanism by which magnolin attenuates prostate cancer cell growth, we estimated the expression levels of Akt/p-Akt, P53, P21, BCL-2, and cleaved Caspase3 by using Western blot 48h after magnolin-treatment of the cells. "
03/01/2017 - "Magnolin inhibits prostate cancer cell growth in vitro and in vivo."
03/01/2017 - "Magnolin may be a novel medicine for prostate cancer therapy."

01/06/2023 - "In this study, we investigated the anti-periodontitis effects of Magnolia kobus extract (MKE) and magnolin as a component of Magnolia kobus (MK) in murine macrophage RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide (LPS). "

11/14/2022 - "Antiproliferative potential of Physalis peruviana-derived magnolin against pancreatic cancer: a comprehensive in vitro and in silico study."