TAN 67

08/01/2001 - "TAN-67 (0.1 mg/kg) also produced a significant reduction in infarct size compared to control (18+/-4%v 60+/-3%, P<0.001). "
01/01/2018 - "Our results showed that post-ischemic administration of Tan-67 (3 mg/kg or 4.5 mg/kg) was neuroprotective as shown by decreased infarct volume and neuronal loss following I/R. "
04/01/2001 - "Control animals, injected with saline 48 h prior to I/R, had an infarct size/area at risk (IS/AAR) of 61.6 +/- 1.6.48-h pretreatment with TAN-67 (30 mg/kg), a delta1-opioid receptor agonist, maximally reduced IS/AAR (31.2 +/- 6.5). "
08/01/2000 - "TAN-67 significantly reduced infarct size/area at risk (29.6 +/- 3.3) versus control (63. "
01/01/2018 - "Conversely, naltrindole abolished Tan-67 neuroprotection in infarct volume. "

10/01/2006 - "Application of morphine and Tan-67 at 24 hours before permanent right middle cerebral arterial occlusion reduced brain infarct volume and improved neurologic functional outcome assessed 24 hours after the occlusion in adult male rats. "

05/01/2003 - "In contrast, TAN-67 improved vagal bradycardia by 30-35%. "

10/01/2006 - "Application of morphine and Tan-67 at 24 hours before permanent right middle cerebral arterial occlusion reduced brain infarct volume and improved neurologic functional outcome assessed 24 hours after the occlusion in adult male rats. "

04/06/2001 - "The mechanisms involved in spinal pain modulation induced by (+) and (-) TAN-67 were also described."
11/03/1999 - "administration of (+)-TAN-67 (1 to 10 ng) in mice produced a marked pain-like aversive responses. "
04/06/2001 - "The pharmacological profile of delta opioid receptor ligands, (+) and (-) TAN-67 on pain modulation."
12/29/2000 - "The present study was designed to investigate the effect of a selective GABA(B) receptor agonist baclofen on the pain-like nociceptive behavior (scratching, biting and licking) induced by intrathecal (i.t.) injection of N-methyl-D-aspartate (NMDA) or (+)TAN-67, the enantiomorphs of 2-methyl-4aalpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aalpha-octahydro-quinolino[2,3,3g]isoquinoline (TAN-67), in the mouse. "