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SIN 1C

a metabolite of molsidomine

Also Known As:

N-(morpholinoimino)acetonitrile; N-morpholinoiminoacetonitrile; SIN-1C; morpholinoiminoacetonitrile

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitriles: 227
  - Acetonitriles: 2
    - SIN 1C: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - SIN 1C: 4

Related Diseases

1.	Renal Insufficiency (Renal Failure) 11/01/1993 - "No differences were found for fe and fe(N) between day 1 and day 4. As SIN 1 is degraded in plasma very rapidly and as SIN 1C is cleared mainly extrarenally, any restrictions concerning repetitive SIN 1 dosage regimen should not be considered for CHD-patients with renal failure."
2.	Reperfusion Injury 01/01/1998 - "Experimental data show additional mechanism of action of the drug: SIN-1C metabolites protects the reoxygenated cardiomyocyte from post-reperfusion damage. " 03/01/1995 - "It was investigated whether SIN-1C, a metabolite of molsidomine, can protect against reperfusion injury in canine hearts in vivo. "
3.	Ischemia 01/01/1998 - "To simulate ischemia-reperfusion, isolated adult rat cardiomyocytes were incubated at pH 6.4 under anoxia and reoxygenated at pH 7.4 in presence or absence of SIN-1C. "
4.	Infarction (Infarctions) 03/01/1995 - "A reduction in infarct size (percent of area at risk) was seen in the SIN-1C group (11.4 +/- 2.8%) compared with the placebo group (24.4 +/- 3.9%, p < 0.05). " 03/01/1995 - "Intracoronary SIN-1C during reperfusion reduces infarct size in dog."
5.	Hypoxia (Hypoxemia) 01/01/1998 - "To simulate ischemia-reperfusion, isolated adult rat cardiomyocytes were incubated at pH 6.4 under anoxia and reoxygenated at pH 7.4 in presence or absence of SIN-1C. "

Related Drugs and Biologics

1.	Molsidomine (SIN 10)