3- phenyl- 4- hydroxy- 7- chloroquinolin- 2(1H)- one
an NMDA/glycine site antagonist; structure given in first source
Also Known As:
MDL 104,653; MDL 104653; MDL-104,653; MDL-104653
Networked: 1
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Related Diseases
1. | Seizures (Absence Seizure)
02/14/1995
- " A lower dose of MDL 104,653 (37 mumol/kg) had no significant effect on either motor seizures or after-discharge duration. " 02/14/1995
- " MDL 104,653 protects against sound-induced clonic seizures in DBA/2 mice following intracerebroventricular (ED50 = 19.1 nmol, 30 min), intraperitoneal (i.p.; ED50 = 6.1 mumol/kg, 45 min), or oral (ED50 = 23.0 mumol/kg, 2 h) administration. " 02/14/1995
- " Anticonvulsant activity of a novel NMDA/glycine site antagonist, MDL 104,653, against kindled and sound-induced seizures."
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