|1.||Altmann, Karl-Heinz: 2 articles (07/2009 - 01/2006)|
|2.||Drzewoski, Józef: 1 article (02/2013)|
|3.||Rogalska, Aneta: 1 article (02/2013)|
|4.||Gajek, Arkadiusz: 1 article (02/2013)|
|5.||Szwed, Marzena: 1 article (02/2013)|
|6.||Śliwińska, Agnieszka: 1 article (02/2013)|
|7.||Marczak, Agnieszka: 1 article (02/2013)|
|8.||Jóźwiak, Zofia: 1 article (02/2013)|
|9.||Merz, Philipp: 1 article (07/2009)|
|10.||Pfeiffer, Bernhard: 1 article (07/2009)|
07/01/1997 - "Epothilone A induces apoptosis in neuroblastoma cells with multiple mechanisms of drug resistance."
07/01/1997 - "However, in contrast to paclitaxel, epothilone A was also effective against a constitutively Pgp-expressing, multidrug resistant neuroblastoma cell line (SK-N-SH). "
07/01/1997 - "Like paclitaxel, epothilone A induced apoptosis in neuroblastoma cells which exhibit constitutive cytoplasmic sequestration of p53 and, hence, an impaired DNA-damage-dependent apoptosis. "
|2.||Ovarian Neoplasms (Ovarian Cancer)
02/01/2013 - "Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B."
02/01/2013 - "The aim of this study was to compare the effects of epothilone A (Epo A) and epothilone B (Epo B) on ovarian cancer cell line SKOV-3 with those of paclitaxel (PTX), a classic taxane. "
07/15/2009 - "The SAR of a series of new epothilone A derivatives with a 2-substituted-1,3-oxazoline moiety trans-fused to the C12-C13 bond of the deoxy macrocycle have been investigated with regard to tubulin polymerization induction and cancer cell growth inhibition. "
01/01/2006 - "Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition."
08/30/2005 - "Although less potent than paclitaxel in several human cancer cell lines, cyclostreptin was active against cells resistant to paclitaxel and epothilone A. "
09/01/2005 - "We present the cases of two patients diagnosed with non-microcytic lung carcinoma who were treated with epothilone, a new chemotherapeutic agent which disrupts microtubule dynamics. "
03/14/2000 - "To identify tubulin residues important for epothilone binding, we have isolated two epothilone-resistant human ovarian carcinoma sublines derived in a single-step selection with epothilone A or B. "
|2.||epothilone B (EPO906)
|6.||Excipients (Suspending Agents)