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cyproconazole

inhibits ergosterol biosynthesis in fungi

Also Known As:

1H-1,2,4-Triazole-1-ethanol, alpha-(4-chlorophenyl)-alpha-(1-cyclopropylethyl)-

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - cyproconazole: 8

Experts

1.	Chen, Ming: 1 article (02/2021)
2.	Chen, Ran: 1 article (02/2021)
3.	Fan, Jun: 1 article (02/2021)
4.	Guo, Dong: 1 article (02/2021)
5.	He, Rujian: 1 article (02/2021)
6.	Liang, Chuying: 1 article (02/2021)
7.	Song, Haiyan: 1 article (02/2021)
8.	Zhang, Weiguang: 1 article (02/2021)
9.	Zhang, Zhifeng: 1 article (02/2021)
10.	Zhao, Mengjiu: 1 article (02/2021)

Related Diseases

1.	Infections 01/01/2013 - "All fungicides were effective in reducing disease infections, except for cyproconazole, propamocarb + fosetyl-Al, and K phosphite that were the least effective in reducing C. "
2.	Hypertrophy 09/01/2007 - "In wild-type mice, 200 ppm cyproconazole caused liver hypertrophy, increased liver weight and cell proliferation, single-cell necrosis and fat vacuolation, effects generally similar to those caused by 850 ppm phenobarbital. " 07/31/2013 - "To clarify the dose-response relationship between constitutive androstane receptor (CAR) activity and induction of cytochrome P450 2B (CYP2B) expression and hypertrophy by triazole fungicides in mouse liver, three dose levels of cyproconazole (Cypro), tebuconazole (Teb), fluconazole (Flu), and phenobarbital (PB), a typical CYP2B inducer, were administrated in diet to male wild-type (WT) and CAR-knockout (CARKO) mice for one week. "
3.	Liver Cell Adenoma (Hepatocellular Adenoma) 09/01/2007 - "Cyproconazole, a triazole fungicide, causes hepatocellular adenomas and carcinomas in CD-1 mice at dose levels of 100 and 200 ppm. The constitutive androstane receptor (CAR) has been shown to play a significant role in the overall mode of action for several nongenotoxic rodent carcinogens such as phenobarbital. "
4.	Necrosis 09/01/2007 - "In wild-type mice, 200 ppm cyproconazole caused liver hypertrophy, increased liver weight and cell proliferation, single-cell necrosis and fat vacuolation, effects generally similar to those caused by 850 ppm phenobarbital. "
5.	Fatty Liver 01/01/2018 - "Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro: A Case Study with Cyproconazole." 01/01/2018 - "Moreover, cyproconazole provoked a disruption of mitochondrial functions and induced triglyceride accumulation and the formation of fatty liver cells as described in the AOP. "

Related Drugs and Biologics

1.	Phosphites
2.	fosetyl-Al (Aliette)
3.	propamocarb
4.	Fluconazole (Zonal)
5.	Triazoles
6.	Phenobarbital (Luminal)
7.	Constitutive Androstane Receptor
8.	Triglycerides (Triacylglycerol)
9.	Cytochrome P-450 Enzyme System (Cytochrome P450)
10.	Carcinogens