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hydromorphone-3-glucuronide

major metabolite of hydromorphone

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Morphinans: 33
      - Morphine Derivatives: 39
        Hydromorphone: 766
        hydromorphone-3-glucuronide: 6
Organic Chemicals: 133
- Carboxylic Acids: 973
Carbohydrates: 22023
- Sugar Acids: 4
  - Uronic Acids: 152
    - Glucuronates: 3
      - hydromorphone-3-glucuronide: 6

Experts

1.	Daron, Susan M: 1 article (07/2013)
2.	Juba, Katherine M: 1 article (07/2013)
3.	Wahler, Robert G: 1 article (07/2013)
4.	McCann, Shawn: 1 article (03/2010)
5.	Yaksh, Tony L: 1 article (03/2010)
6.	von Gunten, Charles F: 1 article (03/2010)
7.	Davison, Sara N: 1 article (11/2008)
8.	Mayo, Patrick R: 1 article (11/2008)
9.	McErlane, K M: 1 article (05/2002)
10.	Ong, M C: 1 article (05/2002)

Related Diseases

1.	Myoclonus (Nocturnal Myoclonus) 03/01/2010 - "The primary goal of this study was to determine plasma levels of morphine-3-glucuronide (M3G) or hydromorphone-3-glucuronide (H3G) in patients demonstrating myoclonus and identify any trends or associations between the two. " 07/01/2000 - "7. Following systemic administration, morphine and HMOR are metabolized primarily to the corresponding 3-glucuronide metabolites, morphine-3-glucuronide (M3G) and hydromorphone-3-glucuronide (H3G), which are not only devoid of analgesic activity but evoke a range of dose-dependent excitatory behaviours, including allodynia, myoclonus and seizures, following intracerebroventricular (i.c.v.) administration to rats. "
2.	Neoplasms (Cancer) 01/01/1995 - "Steady-state pharmacokinetics of hydromorphone and hydromorphone-3-glucuronide in cancer patients after immediate and controlled-release hydromorphone." 05/01/2002 - "1. Hydromorphone-3-glucuronide, dihydromorphine, dihydroisomorphine, dihydromorphine-3-glucuronide and dihydroisomorphine-3-glucuronide were isolated from a cancer patient's urine and identified as metabolites of hydromorphone by comparison with synthetic standards using LC/MS/MS with gradient elution. "
3.	Hyperalgesia 07/01/2013 - "Accumulation of the active morphine-3-glucuronide (M3G) and hydromorphone-3-glucuronide (H3G) metabolites is one proposed mechanism for the development of neuroexcitatory effects including allodynia and opioid-induced hyperalgesia (OIH). " 07/01/2000 - "7. Following systemic administration, morphine and HMOR are metabolized primarily to the corresponding 3-glucuronide metabolites, morphine-3-glucuronide (M3G) and hydromorphone-3-glucuronide (H3G), which are not only devoid of analgesic activity but evoke a range of dose-dependent excitatory behaviours, including allodynia, myoclonus and seizures, following intracerebroventricular (i.c.v.) administration to rats. "
4.	Chronic Renal Insufficiency 11/01/2008 - "Pain management in chronic kidney disease: the pharmacokinetics and pharmacodynamics of hydromorphone and hydromorphone-3-glucuronide in hemodialysis patients."
5.	Seizures (Absence Seizure) 07/01/2000 - "7. Following systemic administration, morphine and HMOR are metabolized primarily to the corresponding 3-glucuronide metabolites, morphine-3-glucuronide (M3G) and hydromorphone-3-glucuronide (H3G), which are not only devoid of analgesic activity but evoke a range of dose-dependent excitatory behaviours, including allodynia, myoclonus and seizures, following intracerebroventricular (i.c.v.) administration to rats. "

Related Drugs and Biologics

1.	morphine-3-glucuronide
2.	Hydromorphone (Dilaudid)
3.	Morphine (MS Contin)
4.	Dihydromorphine
5.	Opioid Analgesics (Opioids)
6.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Pain Management
2.	Renal Dialysis (Hemodialysis)