Neurogenic differentiation factor 1

basic helix-loop-helix protein involved in neurogenic differentiation

Also Known As:

NEUROD1 protein; NeuroD protein; NeuroD protein, Xenopus; NeuroD protein, zebrafish; NeuroD1 protein, Xenopus; Nrd protein, zebrafish; cnd protein, C elegans; cnd-1 protein, C elegans

Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Kasim, Vivi: 2 articles (12/2021 - 01/2020)
2.	Li, Yanjun: 2 articles (12/2021 - 01/2020)
3.	Miyagishi, Makoto: 2 articles (12/2021 - 01/2020)
4.	Wu, Shourong: 2 articles (12/2021 - 01/2020)
5.	Zhao, Hezhao: 2 articles (12/2021 - 01/2020)
6.	Bai, Xue-Hong: 1 article (02/2022)
7.	Bai, Zhou-Lan: 1 article (02/2022)
8.	Chen, Xiao-Zhen: 1 article (02/2022)
9.	Ding, Xiao-Long: 1 article (02/2022)
10.	He, Jin-Xi: 1 article (02/2022)

Related Diseases

1.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 02/27/2022 - "Recent studies have shown that according to the expression levels of achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), and POU class 2 homeobox 3 (POU2F3), small cell lung cancer (SCLC) can be divided into four subtypes: SCLC-A (ASCL1-dominant), SCLC-N (NEUROD1-dominant), SCLC-P (POU2F3-dominant), and SCLC-I (triple negative or SCLC-inflamed). " 01/01/2023 - "Neurogenic differentiation factor 1 (NEUROD1) is frequently overexpressed in small-cell lung cancer (SCLC). " 07/01/2023 - "Several transcription factors in small cell lung cancer (SCLC), including achaete-scute homolog 1 (ASCL1) and neurogenic differentiation factor 1 (NEUROD1), contribute to rapid tumor growth and early metastatic dissemination. " 12/01/2021 - "While small cell lung cancer (SCLC) has been treated as a single disease historically, recent studies have suggested that SCLC can be classified into molecular subtypes based on the expression of lineage transcription factors such as achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), POU domain class 2 transcription factor 3 (POU2F3) and transcriptional coactivator YAP1 (YAP1). "
2.	Neoplasms (Cancer) 12/01/2021 - "Neurogenic differentiation factor 1 (NeuroD1) is upregulated in various types of tumors; however, its involvement in tumor cell metabolic reprogramming remains unclear. " 04/01/2007 - "Out of 13 bHLH genes tested, 4 genes, i.e., achaete-scute complex-like 1 (ASCL1, HASH1, Mash1), atonal homolog 1 (ATOH1, HATH1, MATH1), NEUROD4 (ATH-3, Atoh3, MATH-3) and neurogenic differentiation factor 1 (NEUROD1, NEUROD, BETA2), showed differential expression among lung tumors and absent or low expression in normal lung. " 01/01/2019 - "Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a new model of SCLC subtypes defined by differential expression of four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). " 07/01/2023 - "Several transcription factors in small cell lung cancer (SCLC), including achaete-scute homolog 1 (ASCL1) and neurogenic differentiation factor 1 (NEUROD1), contribute to rapid tumor growth and early metastatic dissemination. "
3.	Type 2 Diabetes Mellitus (MODY) 10/15/2021 - "A neurogenic differentiation factor 1 (NEUROD1) gene mutation causes beta-cells dysfunction, inadequate insulin secretion, and hyperglycaemia (MODY 6). " 12/01/2002 - "To evaluate the role of polymorphism in the neurogenic differentiation factor 1(Neuro D) gene in Chinese patients with type 2 diabetes mellitus. " 12/01/2002 - "[Association of polymorphism in neurogenic differentiation factor 1 gene with type 2 diabetes]." 04/08/2002 - "So far, six MODY genes have been identified (MODY1-6): hepatocyte nuclear factor (HNF-4 alpha), glucokinase, HNF-1 alpha, HNF-1 beta, insulin promoter factor 1(IPF-1), and neurogenic differentiation factor 1 (NEUROD1). "
4.	Carcinogenesis 01/01/2020 - "Neurogenic differentiation factor 1 promotes colorectal cancer cell proliferation and tumorigenesis by suppressing the p53/p21 axis."
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "Neurogenic differentiation factor 1 promotes colorectal cancer cell proliferation and tumorigenesis by suppressing the p53/p21 axis."

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Transcription Factor 3
3.	Hepatocyte Nuclear Factors
4.	Proteins (Proteins, Gene)
5.	Insulin (Novolin)
6.	Glucokinase