thionisoxetine

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2 relevant articles (0 outcomes, 0 trials/studies) found for this Bio-Agent

Description: norepinephrine inhibitor; an analog of nisoxetine; (R)-enantionmer is significantly more potent than (S)-enantiomer

Also Known As:

(R)-thionisoxetine; (S)-thionisoxetine; 3-ortho-thiomethylphenoxy-N-methyl-3-phenylpropylamine; LY 368975; LY-368975; LY368975

Bio-Agent Context: Research Results

Organic Chemicals: 40

Related Diseases

1.	Pain (Aches) 11/01/2004 - "Low doses of the SSRI paroxetine or the NRI thionisoxetine alone did not have an effect on late phase paw-licking pain behavior in the formalin model of persistent pain; however, when combined, significantly attenuated this pain behavior" Get all the results and reference details, order at left...
2.	Hyperalgesia 12/01/2006 - "In the presence of fluoxetine, the potency of thionisoxetine in reversing carrageenan-induced hyperalgesia and allodynia was significantly increased by approximately 100-fold and brain concentrations of thionisoxetine were increased by 1.1- to 5-fold" 12/01/2006 - "In addition, the selective noradrenergic reuptake inhibitors (NRIs) thionisoxetine (0.03-10mg/kg, i.p.) and desipramine (1-30mg/kg, i.p.) also produced complete reversals of carrageenan-induced thermal hyperalgesia" Get all the results and reference details, order at left...
2 Diseases and 2 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Paroxetine (Paxil)
2.	Formaldehyde (Formol)
3.	Fluoxetine (Prozac)
4.	Desipramine (Pertofrane)
5.	Carrageenan
5 Drugs and Important Bio-Agents and 2 more articles analyzed in the Research Interface, order at left...

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